Research output per year
Research output per year
Project Details
Description
Dynamic growth of Epidermal growth factor receptor clusters by super-resolution microscopy of live human carcinoma cells
Having developed the project and applied, I was successfully awarded six months of JSPS research time worth over £18000.
At OIST I worked in the renowned group of Prof. Akihiro Kusumi in the fundamental biophysics of precancer. We developed a quantitative platform for single molecule tracking in CHO-K1 cells for study of ErbB receptor dynamics and function, and for the first time directly visualised transient dimers of EGF-EGFR-HER2. This project describes a minimal in vivo system ideal for quantitative study of the development of heterocomplexes and activated clusters. It is an invaluable step in disentangling the networks governing receptor activation and precancerous pathology in general.
Having developed the project and applied, I was successfully awarded six months of JSPS research time worth over £18000.
At OIST I worked in the renowned group of Prof. Akihiro Kusumi in the fundamental biophysics of precancer. We developed a quantitative platform for single molecule tracking in CHO-K1 cells for study of ErbB receptor dynamics and function, and for the first time directly visualised transient dimers of EGF-EGFR-HER2. This project describes a minimal in vivo system ideal for quantitative study of the development of heterocomplexes and activated clusters. It is an invaluable step in disentangling the networks governing receptor activation and precancerous pathology in general.
| Short title | Postdoctoral Fellowship |
|---|---|
| Acronym | JSPS |
| Status | Finished |
| Effective start/end date | 23/03/19 → 23/06/19 |
Research output
- 1 Article
-
Critical roles for EGFR and EGFR-HER2 clusters in EGF binding of SW620 human carcinoma cells
Wollman, A. J. M., Fournier, C., Llorente-Garcia, I., Harriman, O., Payne-Dwyer, A. L., Shashkova, S., Zhou, P., Liu, T.-C., Ouaret, D., Wilding, J., Kusumi, A., Bodmer, W. & Leake, M. C., 25 May 2022, In: Journal of the Royal Society Interface. 19, 190, 11 p., 20220088.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Activities
- 1 Types of Award - Fellowship awarded competitively
-
Japanese Society for the Promotion of Science (JSPS) Postdoctoral Fellowship (Short-Term)
Payne-Dwyer, A. (Advisor)
23 Mar 2019Activity: Other › Types of Award - Fellowship awarded competitively