Mechanistic insights into lytic polysaccharide monooxygenases

Research output

Research output per year 2018 2018 2019 2020 2022 2023 2024

• 14 Article
• 1 Chapter (peer-reviewed)
• 1 Review article

Research output per year

Research output per year

Search results

• 2024

  Structural Dissection of Two Redox Proteins from the Shipworm Symbiont Teredinibacter turnerae

  Rajagopal, B. S., Yates, N., Smith, J., Paradisi, A., Tetard-Jones, C., Willats, W. G. T., Marcus, S., Knox, J. P., ́Firdaus-Raih, M., Henrissat, B., Davies, G. J., Walton, P. H., Parkin, A. & Hemsworth, G. R., 1 Mar 2024, In: IUCrJ. 11, 2, p. 260-274 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2023

  Mapping the Initial Stages of a Protective Pathway that Enhances Catalytic Turnover by a Lytic Polysaccharide Monooxygenase

  Zhao, J., Zhuo, Y., Diaz, D. E., Shanmugam, M., Telfer, A. J., Lindley, P. J., Kracher, D., Hayashi, T., Seibt, L. S., Hardy, F. J., Manners, O., Hedison, T. M., Hollywood, K. A., Spiess, R., Cain, K. M., Diaz-Moreno, S., Scrutton, N. S., Tovborg, M., Walton, P. H. & Heyes, D. J. & 1 others, Green, A. P., 20 Sept 2023, In: Journal of the American Chemical Society. 145, 37, p. 20672-20682 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2022

  Deletion of AA9 Lytic Polysaccharide Monooxygenases Impacts A. nidulans Secretome and Growth on Lignocellulose

  Terrasan, C. R. F., Rubio, M., Gerhardt, J., Cairo, J., Contesini, F., Zubieta, M., Lopes de Figueiredo, F., Valadares, F., Correa, T., Mario, M., Telma, F., Davies, G. J., Walton, P. H. & Damasio, A., 6 Jun 2022, In: Microbiology spectrum. 10, 3, 16 p., e0212521.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Mapping the protonation states of the histidine brace in an AA10 lytic polysaccharide monooxygenase using CW-EPR spectroscopy and DFT calculations

  Lindley, P. J., Parkin, A., Davies, G. J. & Walton, P. H., 1 May 2022, In: FARADAY DISCUSSIONS. 234, p. 336–348

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Structural perturbations of substrate binding and oxidation state changes in a lytic polysaccharide monooxygenase

  Walton, P. H. & Davies, G. J., 8 Oct 2022, (E-pub ahead of print) In: Journal of Biological Inorganic Chemistry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2021

  Secreted pectin monooxygenases drive plant infection by pathogenic oomycetes

  Sabbadin, F., Urresti, S., Henrissat, B., Avrova, A. O., Welsh, L. R. J., Lindley, P., Csukai, M., Squires, J. N., Walton, P. H., Davies, G. J., Bruce, N. C., Whisson, S. C. & McQueen Mason, S. J., 13 Aug 2021, (E-pub ahead of print) In: Science. 373, 6556, p. 774-779 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2020

  Activation of O₂and H₂O₂by Lytic Polysaccharide Monooxygenases

  Wang, B., Wang, Z., Davies, G. J., Walton, P. H. & Rovira, C., 19 Oct 2020, In: ACS Catalysis. p. 12760-12769 10 p.

  Research output: Contribution to journal › Article › peer-review

• A fungal family of lytic polysaccharide monooxygenase-like copper proteins

  Walton, P. H., Labourel, A., Frandsen, K. E. H., Zhang, F., Brouilly, N., Grisel, S., Haon, M., Ciano, L., Ropartz, D., Fanuel, M., Martin, F., Navarro, D., Rosso, M.-N., Tandrup, T., Bissaro, B., Johansen, K., Zerva, A., Henrissat, B., Lo Leggio, L. & Berrin, J.-G., 13 Jan 2020, In: NATURE CHEMICAL BIOLOGY. p. 1-11 11 p., https://doi.org/10.1038/s41589-019-0438-8.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Insights from semi-oriented EPR spectroscopy studies into the interaction of lytic polysaccharide monooxygenases with cellulose

  Ciano, L., Paradisi, A., Hemsworth, G. R., Tovborg, M., Davies, G. J. & Walton, P. H., 3 Mar 2020, In: Dalton Transactions. 49, p. 3413-3422 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Mechanistic basis of substrate-O2 coupling within a chitin-active lytic polysaccharide monooxygenase: an integrated NMR/EPR study

  Walton, P. H., Lindley, P., Davies, G. J., Paradisi, A., Ciano, L., Aachmann, F., Courtade, G., Eijsink, V., Sorlie, M., Forsberg, Z. & Wimmer, R., 28 Jul 2020, In: Proceedings of the National Academy of Sciences USA. p. 1-12 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2019

  Formation of a copper(II)-tyrosyl complex at the active site of lytic polysaccharide monooxygenases following oxidation by H2O2

  Paradisi, A., Johnston, E. M., Tovborg, M., Nicoll, C., Ciano, L., Dowle, A., McMaster, J., Hancock, Y., Davies, G. J. & Walton, P. H., 20 Nov 2019, In: Journal of the American Chemical Society. 141, 46, p. 18585-18599 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• The Molecular Mechanisms of Oxygen Activation and Hydrogen Peroxide Formation in Lytic Polysaccharide Monooxygenases

  Wang, B., Walton, P. H. & Rovira, C., 22 Apr 2019, (E-pub ahead of print) In: ACS Catalysis. 30 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2018

  QM/MM studies into the H2O2-dependent activity of lytic polysaccharide monooxygenases: Evidence for the formation of a caged hydroxyl radical intermediate

  Wang, B., Johnston, E. M., Li, P., Shaik, S., Davies, G. J., Walton, P. H. & Rovira, C., 11 Jan 2018, (E-pub ahead of print) In: ACS Catalysis. 8, p. 1346–1351

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Structural studies of the unusual metal-ion site of the GH124 endoglucanase from Ruminiclostridium thermocellum

  Walton, P. H., Davies, G. J., Urresti, S., Cartmell, A. & Liu, F., 1 Aug 2018, In: Acta Crystallographica Section F: Structural Biology Communications. 74, 8, p. 496-505

  Research output: Contribution to journal › Article › peer-review

  Open Access