Modify-Catch-Release-Repeat: Reversible bioconjugations for controlled release of small molecules from antibodies and their fragments

Fascione, Martin Anthony (Principal investigator)
Davies, Gideon John (Co-investigator)
Southgate, Jenny (Co-investigator)
Ungar, Dani (Co-investigator)

Project: Research project (funded) › Research

Status	Finished
Effective start/end date	1/01/19 → 31/03/23

Funding

EPSRC: £397,838.40

3 Article

A tale of two bioconjugations: pH controlled divergent reactivity of protein a-oxo aldehydes in competing a-oxo-Mannich and catalyst-free aldol ligations
Keenan, T., Spears, R. J., Akkad, S., Mahon, C. S., Hatton, N. E., Walton, J., Noble, A., Yates, N. D., Baumann, C. G., Parkin, A., Signoret, N. & Fascione, M. A., 19 Nov 2021, In: ACS Chemical Biology. 16, 11, p. 2387-2400 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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Chemoenzymatic synthesis of 3-deoxy-3-fluoro-L-fucose and its enzymatic incorporation into glycoconjugates
Valverde, P., Vendeville, J-B., Hollingsworth, K., Mattey, A. P., Keenan, T., Chidwick, H., Ledru, H., Huonnic, K., Light, M. E., Turner, N., Jimenez Barbero, J., Galan, M. C., Fascione, M. A., Flitsch, S., Turnbull, W. B. & Linclau, B., 29 Apr 2020, (E-pub ahead of print) In: Chemical Communications. 5
Research output: Contribution to journal › Article › peer-review

Open Access
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Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation
Brabham, R., Keenan, T., Husken, A., Bilsborrow, J., McBerney, R., Kumar, V., Turnbull, W. B. & Fascione, M. A., 14 May 2020, (E-pub ahead of print) In: Organic and Biomolecular Chemistry.
Research output: Contribution to journal › Article › peer-review

Open Access
File