Organocatalytic sigmatropic rearrangments

Project: Other projectMiscellaneous project

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Description

The use of organocatalysis to produce chiral centres have shown great use and utility to chemists who need to synthesise target molecules due to their biological activity. The reasons for this are due to the fact the catalysts are small, non-toxic, cheap and produce chiral centres with high enantioselectivies. Despite the large amount of research in asymmetric organocatalysis, they have been applied to only a handful of reactions. This project aims to explore the use of organocatalysis to a major class of reactions - [3,3] sigmatropic rearrangements as a mild method to produce chiral molecules. We are investigating the use of easily available amino acids to catalyse the Carroll rearrangment in an asymmetric manner.
StatusActive
Effective start/end date23/10/12 → …

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