Programming DNA topology: from folding DNA minicircles to revealing the spatial organization of bacterial genomes

NOY, AGNES (Principal investigator)
LEAKE, MARK CHRISTIAN (Co-investigator)

Physics

Project: Research project (funded) › Research

Status	Finished
Effective start/end date	1/07/16 → 31/12/21

Funding

EPSRC: £612,742.00

14 Article
1 Comment/debate
1 Review article

The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states
HOWARD, J. A. L., Ambrose, B., Abdelhamid, M., FRAME, L., ALEVROPOULOS-BORRILL, N., Ejaz, A., DRESSER, L., Dienerowitz, M., QUINN, S., Squires, A., NOY, A., Craggs, T. & LEAKE, M. C., 21 Jan 2026, In: Nucleic Acids Research. 54, 2, 21 p., gkaf1483.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Atomic Description of the Reciprocal Action between Supercoils and Melting Bubbles on Linear DNA
Burman, M. & Noy, A., 24 Jan 2025, In: Physical Review Letters. 134, 3, 6 p., 038403.
Research output: Contribution to journal › Article › peer-review

Open Access
File
HU searches and binds specific DNA via a multi-step process combining weak electrostatic binding, protein reorientation and DNA flexibility
Chan, E., LEAKE, M. C. & NOY, A., 27 Oct 2025, In: JACS Au. 5, 10, p. 4870–4878 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File

Highest-Resolution Images Of DNA Ever Reveal How It “Dances”
Noy, A. (Advisor)
2021
Activity: Other › Media (Press)
'Dancing DNA' caught up-close in world's highest-resolution pics and video of DNA molecule
Noy, A. (Advisor)
2021
Activity: Other › Media (Press)
First videos to show the helix of ‘dancing DNA’ developed by scientists
Noy, A. (Advisor)
2021
Activity: Other › Media (Press)

IHF bends and bridges DNA in a multiplicity of states
Noy, A. (Creator), University of York, 23 Sept 2020
DOI: 10.15124/0b602b82-16e9-4fa8-9a64-a15d7373f80e
Dataset
Simulations of supercoiled minicircles bound to IHF
Noy, A. (Creator) & Watson, G. D. (Creator), University of York, 31 Mar 2022
DOI: 10.15124/dfc206ca-f6e1-43af-b677-8dd316d3dcf0
Dataset
Simulations of circular RNAs from the Rolling Circle RNA synthesis
Noy, A. (Creator), University of York, 1 Oct 2021
DOI: 10.15124/b92977bd-f016-4740-8b4a-f86c68d5eb2c
Dataset