Regulation of cancer cell migration by voltage-gated sodium channels

Search results

• 2020

  Metastatic breast cancer cells induce altered microglial morphology & electrical excitability in vivo

  Simon, A. M., Yang, M., Marrison, J., James, A., Hunt, M. J., O'Toole, P. J., Kaye, P., Whittington, M. A., Chawla, S. & Brackenbury, W., 19 Mar 2020, In: Journal of Neuroinflammation. 17, 15 p., 87.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2019

  Voltage-dependent activation of Rac1 by Nav1.5 channels promotes cell migration

  Yang, M., James, A. D., Suman, R., Kasprowicz, R. M. R., Nelson, M., O'Toole, P. J. & Brackenbury, W. J., 15 Oct 2019, (E-pub ahead of print) In: Journal of cellular physiology. 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2017

  IK channel activation increases tumor growth and induces differential behavioral responses in two breast epithelial cell lines

  Thurber, A., Nelson, M., Frost, C., Levin, M., Brackenbury, W. J. & Kaplan, D. L., 21 Mar 2017, In: Oncotarget. 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Visualising tumour cell-microglial interactions in vivo using two photon intravital imaging

  Yang, M., Marrison, J., O'Toole, P. J., Whittington, M. A., Kaye, P., Chawla, S. & Brackenbury, W. J., 15 Jun 2017.

  Research output: Contribution to conference › Abstract › peer-review

• 2016

  Blockade of voltage-gated sodium channels inhibits invasion of endocrine resistant breast cancer cells

  Mohammed, F., Khajah, M., Yang, M., Brackenbury, W. & Luqmani, Y., Jan 2016, In: International journal of oncology. 48, 1, p. 73-83

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Ion Channels in Cancer

  Brackenbury, W. J., 28 Jul 2016, Ion Channels In Health and Disease, 1st Edition. Pitt, G. (ed.). 1 ed. Academic Press, (Perspectives in Translational Cell Biology).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• 2015

  Dual roles of voltage-gated sodium channels in development and cancer

  Patel, F. & Brackenbury, W., 20 Nov 2015, In: International Journal of Developmental Biology. 59, p. 357-366

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

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• Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo

  Nelson, M., Yang, M., Millican-Slater, R. & Brackenbury, W., 6 Oct 2015, In: Oncotarget. 6, 32, p. 32914-32929

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Sodium channel-inhibiting drugs and survival of breast, colon and prostate cancer: a population-based study

  Fairhurst, C. M., Watt, I., Martin, F., Bland, M. & Brackenbury, W., 18 Nov 2015, In: Scientific Reports. 5, p. 16758

  Research output: Contribution to journal › Article › peer-review

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• Therapeutic value of voltage-gated sodium channel inhibitors in breast, colorectal and prostate cancer: a systematic review

  Martin, F., Ufodiama, C., Watt, I., Bland, M. & Brackenbury, W., 12 Nov 2015, In: Frontiers in Pharmacology. 6, 273.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis.

  Nelson, M., Yang, M., Dowle, A., Thomas, J. & Brackenbury, W., 27 Jan 2015, In: Molecular Cancer. 14, 13.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2014

  Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation

  Fraser, S. P., Ozerlat-Gunduz, I., Brackenbury, W. J., Fitzgerald, E. M., Campbell, T. M., Coombes, R. C. & Djamgoz, M. B. A., 19 Mar 2014, In: Philosophical Transactions Of The Royal Society Of London Series B - Biological Sciences. 369, 1638, 12 p., 20130105.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• The sodium channel β1 subunit mediates outgrowth of neurite-like processes on breast cancer cells and promotes tumour growth and metastasis

  Nelson, M., Millican-Slater, R., Forrest, L. C. & Brackenbury, W. J., 15 Nov 2014, In: International Journal of Cancer. 135, 10, p. 2338-2351

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2013

  Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability

  Brackenbury, W. J., Yuan, Y., O'Malley, H. A., Parent, J. M. & Isom, L. L., 15 Jan 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 3, p. 1089-1094 6 p.

  Research output: Contribution to journal › Article › peer-review

• Membrane potential and cancer progression

  Yang, M. & Brackenbury, W. J., 17 Jul 2013, In: Frontiers in physiology. 4, 10 p., 185.

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

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• 2012

  Therapeutic potential for phenytoin: targeting Na_v1.5 sodium channels to reduce migration and invasion in metastatic breast cancer

  Yang, M., Kozminski, D. J., Wold, L. A., Modak, R., Calhoun, J. D., Isom, L. L. & Brackenbury, W. J., Jul 2012, In: BREAST CANCER RESEARCH AND TREATMENT. 134, 2, p. 603-615 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2011

  Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo

  Lopez-Santiago, L. F., Brackenbury, W. J., Chen, C. & Isom, L. L., 1 Jul 2011, In: Journal of Biological Chemistry. 286, 26, p. 22913-23 11 p.

  Research output: Contribution to journal › Article › peer-review

• Na⁺ Channel ß Subunits: Overachievers of the Ion Channel Family

  Brackenbury, W. J. & Isom, L. L., 28 Sept 2011, In: Frontiers in Pharmacology. 2, 11 p., 53.

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

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• Voltage-Gated Na+ Channel beta 1B: A Secreted Cell Adhesion Molecule Involved in Human Epilepsy

  Patino, G. A., Brackenbury, W. J., Bao, Y., Lopez-Santiago, L. F., O'Malley, H. A., Chen, C., Calhoun, J. D., Lafreniere, R. G., Cossette, P., Rouleau, G. A. & Isom, L. L., 12 Oct 2011, In: Journal of neuroscience. 31, 41, p. 14577-14591 15 p.

  Research output: Contribution to journal › Article › peer-review