Research output per year
Research output per year
Project Details
Description
Triple Diels-Alder Cascades: Development and Application
Layman's description
The development of new synthetic methodology with widespread utility - and its application to prepare compounds of academic and industrial interest
Key findings
1. Further studies of the triple Diels-Alder cascade were carried out.
2. Simple cyclisation reactions were developed to prepare a range of heterocyclic systems (invited paper in Heterocycles).
3. Direct imine acylation (DIA) was developed and applied to prepare a range of heterocycles and the bioactive natural product Evodiamine (paper in Organic Letters).
4. Direct imine acylation (DIA) was applied to complete the first synthesis of the bioactive natural product 'Upenamide and cast doubt on its published structure Evodiamine (paper in Organic Letters).
5. The first synthesis of the bioactive natural product Dievodiamine was developed using an unprecedented organometallic addition process (paper in Organic Letters).
6. The first synthesis of the bioactive extremophile-derived natural product Spriobacillene A was developed using an unprecedented alkyne spirocyclisation process (paper in Organic Letters).
7. The scope of Direct imine acylation (DIA) was dramatically extended and applied to prepare a range of heterocyclic scaffolds (paper submitted).
8. The above advances were widely disseminated to academic and industrial audiences in conference presentations, invited lectures and posters.
9. The PDRA (Dr Will Unsworth) was subsequently employed as a Teaching / Research Fellow at the University of York.
2. Simple cyclisation reactions were developed to prepare a range of heterocyclic systems (invited paper in Heterocycles).
3. Direct imine acylation (DIA) was developed and applied to prepare a range of heterocycles and the bioactive natural product Evodiamine (paper in Organic Letters).
4. Direct imine acylation (DIA) was applied to complete the first synthesis of the bioactive natural product 'Upenamide and cast doubt on its published structure Evodiamine (paper in Organic Letters).
5. The first synthesis of the bioactive natural product Dievodiamine was developed using an unprecedented organometallic addition process (paper in Organic Letters).
6. The first synthesis of the bioactive extremophile-derived natural product Spriobacillene A was developed using an unprecedented alkyne spirocyclisation process (paper in Organic Letters).
7. The scope of Direct imine acylation (DIA) was dramatically extended and applied to prepare a range of heterocyclic scaffolds (paper submitted).
8. The above advances were widely disseminated to academic and industrial audiences in conference presentations, invited lectures and posters.
9. The PDRA (Dr Will Unsworth) was subsequently employed as a Teaching / Research Fellow at the University of York.
| Acronym | TDAC |
|---|---|
| Status | Finished |
| Effective start/end date | 1/04/10 → 31/03/13 |
Funding
- EPSRC: £297,057.00
Research output
- 5 Article
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An Expedient Protecting-Group-Free Total Synthesis of (±)-Dievodiamine
Unsworth, W. P., Kitsiou, C. & Taylor, R. J. K., 20 Jun 2013, In: Organic Letters. 15, 13, p. 3302-3305Research output: Contribution to journal › Article › peer-review
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Direct imine acylation: rapid access to diverse heterocyclic scaffolds
Unsworth, W. P., Kitsiou, C. & Taylor, R. J. K., 18 Jan 2013, In: Organic Letters. 15, 2, p. 258-61 4 p.Research output: Contribution to journal › Article › peer-review
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Direct imine acylation: synthesis of the proposed structures of 'upenamide
Unsworth, W. P., Gallagher, K. A., Jean, M., Schmidt, J. P., Diorazio, L. J. & Taylor, R. J. K., 18 Jan 2013, In: Organic Letters. 15, 2, p. 262-5 4 p.Research output: Contribution to journal › Article › peer-review