β-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining β-L-arabinofuranosidases

Valentina Borlandelli; Wendy A Offen; Olga Moroz; Alba Nin-Hill; Nicholas McGregor; Lars Binkhorst; Akihiro Ishiwata; Zachary Armstrong; Marta Artola; Carme Rovira; Gideon J. Davies; Herman S. Overkleeft

doi:10.1021/acschembio.3c00558

β-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining β-L-arabinofuranosidases

Valentina Borlandelli, Wendy A Offen, Olga Moroz, Alba Nin-Hill, Nicholas McGregor, Lars Binkhorst, Akihiro Ishiwata, Zachary Armstrong, Marta Artola, Carme Rovira, Gideon J. Davies, Herman S. Overkleeft

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	2564–2573
Number of pages	10
Journal	ACS Chemical Biology
Volume	18
Issue number	12
Early online date	5 Dec 2023
DOIs	https://doi.org/10.1021/acschembio.3c00558
Publication status	E-pub ahead of print - 5 Dec 2023

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10.1021/acschembio.3c00558Licence: CC BY

β‑L-Arabinofurano-cyclitolAziridinesAreCovalentBroad-SpectrumInhibitorsandActivity-BasedProbesforRetainingβ‑L‑Arabinofuranosidases
© 2023 The Authors
Final published version, 3.85 MBLicence: CC BY

1 Finished
2 Active

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society
Davies, G. J.
EUROPEAN COMMISSION
1/06/21 → 31/05/27
Project: Research project (funded) › Research
RS Research Professorship
Davies, G. J.
THE ROYAL SOCIETY
1/01/17 → 31/12/27
Project: Research project (funded) › Research
Application of activity-based glycosidase probes for mechanism, enzyme discovery and clinical diagnosis
Davies, G. J.
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
1/01/18 → 31/12/21
Project: Research project (funded) › Research

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Borlandelli, V., Offen, W. A., Moroz, O., Nin-Hill, A., McGregor, N., Binkhorst, L., Ishiwata, A., Armstrong, Z., Artola, M., Rovira, C., Davies, G. J., & Overkleeft, H. S. (2023). β-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining β-L-arabinofuranosidases. ACS Chemical Biology, 18(12), 2564–2573. Advance online publication. https://doi.org/10.1021/acschembio.3c00558

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title = "β-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining β-L-arabinofuranosidases",

author = "Valentina Borlandelli and Offen, {Wendy A} and Olga Moroz and Alba Nin-Hill and Nicholas McGregor and Lars Binkhorst and Akihiro Ishiwata and Zachary Armstrong and Marta Artola and Carme Rovira and Davies, {Gideon J.} and Overkleeft, {Herman S.}",

note = "{\textcopyright} 2023 The Authors",

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day = "5",

doi = "10.1021/acschembio.3c00558",

language = "English",

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Borlandelli, V, Offen, WA, Moroz, O, Nin-Hill, A, McGregor, N, Binkhorst, L, Ishiwata, A, Armstrong, Z, Artola, M, Rovira, C, Davies, GJ & Overkleeft, HS 2023, 'β-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining β-L-arabinofuranosidases', ACS Chemical Biology, vol. 18, no. 12, pp. 2564–2573. https://doi.org/10.1021/acschembio.3c00558

TY - JOUR

T1 - β-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining β-L-arabinofuranosidases

AU - Borlandelli, Valentina

AU - Offen, Wendy A

AU - Moroz, Olga

AU - Nin-Hill, Alba

AU - McGregor, Nicholas

AU - Binkhorst, Lars

AU - Ishiwata, Akihiro

AU - Armstrong, Zachary

AU - Artola, Marta

AU - Rovira, Carme

AU - Davies, Gideon J.

AU - Overkleeft, Herman S.

PY - 2023/12/5

Y1 - 2023/12/5

U2 - 10.1021/acschembio.3c00558

DO - 10.1021/acschembio.3c00558

M3 - Article

SN - 1554-8929

VL - 18

SP - 2564

EP - 2573

JO - ACS Chemical Biology

JF - ACS Chemical Biology

IS - 12

ER -

β-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining β-L-arabinofuranosidases

Bibliographical note

Access to Document

Projects

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society

RS Research Professorship

Application of activity-based glycosidase probes for mechanism, enzyme discovery and clinical diagnosis

Cite this