2-dimethylarsinothioyl acetic acid identified in a biological sample: The first occurrence of a mammalian arsinothioyl metabolite

H R  Hansen; R  Pickford; J  Thomas-Oates; M  Jaspars; J  Feldmann

doi:10.1002/anie.200352740

2-dimethylarsinothioyl acetic acid identified in a biological sample: The first occurrence of a mammalian arsinothioyl metabolite

H R Hansen, R Pickford, J Thomas-Oates, M Jaspars, J Feldmann

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Arsenic in sheep's clothing: the first characterization of a thio-organoarsenate compound (2-dimethylarsinothioyl acetic acid) isolated from a biological source (a rare breed of seaweed-eating sheep; see picture) is reported. The result indicates that mammalian arsenic metabolism is much more complex than has been claimed before, which opens up new questions about the toxicity of such organoarsenothio(y)l compounds.

Original language	English
Pages (from-to)	337-340
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	43
Issue number	3
DOIs	https://doi.org/10.1002/anie.200352740
Publication status	Published - Jan 2004

Keywords

analytical methods
arsenic
bioinorganic chemistry
mass spectrometry
sulfur
ARSENIC-BINDING-PROTEINS
HPLC-ICP-MS
ARSENOSUGARS
SPECIATION
COMPOUND
THIOLS
CELLS

Access to Document

10.1002/anie.200352740

http://dx.doi.org/10.1002/anie.200352740

Cite this

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title = "2-dimethylarsinothioyl acetic acid identified in a biological sample: The first occurrence of a mammalian arsinothioyl metabolite",

abstract = "Arsenic in sheep's clothing: the first characterization of a thio-organoarsenate compound (2-dimethylarsinothioyl acetic acid) isolated from a biological source (a rare breed of seaweed-eating sheep; see picture) is reported. The result indicates that mammalian arsenic metabolism is much more complex than has been claimed before, which opens up new questions about the toxicity of such organoarsenothio(y)l compounds.",

keywords = "analytical methods, arsenic, bioinorganic chemistry, mass spectrometry, sulfur, ARSENIC-BINDING-PROTEINS, HPLC-ICP-MS, ARSENOSUGARS, SPECIATION, COMPOUND, THIOLS, CELLS",

author = "Hansen, {H R} and R Pickford and J Thomas-Oates and M Jaspars and J Feldmann",

year = "2004",

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language = "English",

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journal = "Angewandte Chemie International Edition",

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T2 - The first occurrence of a mammalian arsinothioyl metabolite

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AU - Pickford, R

AU - Thomas-Oates, J

AU - Jaspars, M

AU - Feldmann, J

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AB - Arsenic in sheep's clothing: the first characterization of a thio-organoarsenate compound (2-dimethylarsinothioyl acetic acid) isolated from a biological source (a rare breed of seaweed-eating sheep; see picture) is reported. The result indicates that mammalian arsenic metabolism is much more complex than has been claimed before, which opens up new questions about the toxicity of such organoarsenothio(y)l compounds.

KW - analytical methods

KW - arsenic

KW - bioinorganic chemistry

KW - mass spectrometry

KW - sulfur

KW - ARSENIC-BINDING-PROTEINS

KW - HPLC-ICP-MS

KW - ARSENOSUGARS

KW - SPECIATION

KW - COMPOUND

KW - THIOLS

KW - CELLS

U2 - 10.1002/anie.200352740

DO - 10.1002/anie.200352740

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EP - 340

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 3

ER -