2-Pyrone natural products and mimetics: isolation, characterisation and biological activity

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Research output: Contribution to journal › Literature review › peer-review

Published copy (DOI)

10.1039/b416651p

Author(s)

G P McGlacken
I J S Fairlamb

Department/unit(s)

Chemistry

Publication details

Journal	NATURAL PRODUCT REPORTS
Date	Published - Jun 2005
Issue number	3
Volume	22
Number of pages	17
Pages (from-to)	369-385
Original language	English

Abstract

The review summarises natural products containing the 2-pyrone moiety. An emphasis has been placed upon the biological activity associated with 2-pyrones, particularly with respect to potential therapeutic or anti-microbial agents. Where appropriate, non-natural 2-pyrone analogues are discussed, particularly those derived from natural product lead compounds.

Research areas

HIV PROTEASE INHIBITORS, STRUCTURE-BASED DESIGN, ALGA PHACELOCARPUS-LABILLARDIERI, MARINE RED ALGA, SELECTIVE ACETYLCHOLINESTERASE INHIBITORS, PANCREATIC CHOLESTEROL ESTERASE, TRICYCLIC PYRONE ANALOGS, PENICILLIUM SP FO-4259, TRICHODERMA-METABOLITE 6-N-PENTYL-2H-PYRAN-2-ONE, POTENT NONPEPTIDIC INHIBITORS

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