3-Alkenyl-oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches

TY - JOUR

T1 - 3-Alkenyl-oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches

AU - Millemaggi, Alessia

AU - Taylor, Richard J. K.

PY - 2010/8

Y1 - 2010/8

N2 - The structures and biological activities of naturally occurring 3-alkenyl-oxindoles are reviewed. Important man-made 3-alkenyl-oxindoles are covered, particularly those with pharmaceutical applications such as sunitinib (SU11248), the orally active receptor tyrosine kinase inhibitor marketed by Pfizer as Sutent (R). Traditional synthetic approaches to 3-alkenyl-oxindoles are summarised and then recently developed tandem/telescoped synthetic routes are described.

AB - The structures and biological activities of naturally occurring 3-alkenyl-oxindoles are reviewed. Important man-made 3-alkenyl-oxindoles are covered, particularly those with pharmaceutical applications such as sunitinib (SU11248), the orally active receptor tyrosine kinase inhibitor marketed by Pfizer as Sutent (R). Traditional synthetic approaches to 3-alkenyl-oxindoles are summarised and then recently developed tandem/telescoped synthetic routes are described.

KW - Nitrogen heterocycles

KW - Natural products

KW - Antitumor agents

KW - Domino reactions

KW - Telescoped reactions

KW - PALLADIUM-CATALYZED CYCLIZATION

KW - C-H FUNCTIONALIZATION

KW - PROTEASOME INHIBITORS TMC-95A

KW - DEPENDENT KINASE INHIBITORS

KW - CIMICIFUGA-DAHURICA MAXIM

KW - STEREOSELECTIVE-SYNTHESIS

KW - OXINDOLE ALKALOIDS

KW - SELECTIVE SYNTHESIS

KW - CELL-CYCLE

KW - 2-(ALKYNYL)ARYL ISOCYANATES

UR - http://www.scopus.com/inward/record.url?scp=77955674388&partnerID=8YFLogxK

U2 - 10.1002/ejoc.201000643

DO - 10.1002/ejoc.201000643

M3 - Literature review

SN - 1099-0690

SP - 4527

EP - 4547

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 24

ER -