By the same authors

From the same journal

3-Alkenyl-oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches

Research output: Contribution to journalLiterature review

Published copy (DOI)

Author(s)

Department/unit(s)

Publication details

JournalEuropean Journal of Organic Chemistry
DatePublished - Aug 2010
Issue number24
Number of pages21
Pages (from-to)4527-4547
Original languageEnglish

Abstract

The structures and biological activities of naturally occurring 3-alkenyl-oxindoles are reviewed. Important man-made 3-alkenyl-oxindoles are covered, particularly those with pharmaceutical applications such as sunitinib (SU11248), the orally active receptor tyrosine kinase inhibitor marketed by Pfizer as Sutent (R). Traditional synthetic approaches to 3-alkenyl-oxindoles are summarised and then recently developed tandem/telescoped synthetic routes are described.

    Research areas

  • Nitrogen heterocycles, Natural products, Antitumor agents, Domino reactions, Telescoped reactions, PALLADIUM-CATALYZED CYCLIZATION, C-H FUNCTIONALIZATION, PROTEASOME INHIBITORS TMC-95A, DEPENDENT KINASE INHIBITORS, CIMICIFUGA-DAHURICA MAXIM, STEREOSELECTIVE-SYNTHESIS, OXINDOLE ALKALOIDS, SELECTIVE SYNTHESIS, CELL-CYCLE, 2-(ALKYNYL)ARYL ISOCYANATES

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations