Research output: Contribution to journal › Literature review
Journal | European Journal of Organic Chemistry |
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Date | Published - Aug 2010 |
Issue number | 24 |
Number of pages | 21 |
Pages (from-to) | 4527-4547 |
Original language | English |
The structures and biological activities of naturally occurring 3-alkenyl-oxindoles are reviewed. Important man-made 3-alkenyl-oxindoles are covered, particularly those with pharmaceutical applications such as sunitinib (SU11248), the orally active receptor tyrosine kinase inhibitor marketed by Pfizer as Sutent (R). Traditional synthetic approaches to 3-alkenyl-oxindoles are summarised and then recently developed tandem/telescoped synthetic routes are described.
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