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3-Alkenyl-oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches
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| Journal | European Journal of Organic Chemistry |
|---|---|
| Date | Published - Aug 2010 |
| Issue number | 24 |
| Number of pages | 21 |
| Pages (from-to) | 4527-4547 |
| Original language | English |
Abstract
The structures and biological activities of naturally occurring 3-alkenyl-oxindoles are reviewed. Important man-made 3-alkenyl-oxindoles are covered, particularly those with pharmaceutical applications such as sunitinib (SU11248), the orally active receptor tyrosine kinase inhibitor marketed by Pfizer as Sutent (R). Traditional synthetic approaches to 3-alkenyl-oxindoles are summarised and then recently developed tandem/telescoped synthetic routes are described.
- Nitrogen heterocycles, Natural products, Antitumor agents, Domino reactions, Telescoped reactions, PALLADIUM-CATALYZED CYCLIZATION, C-H FUNCTIONALIZATION, PROTEASOME INHIBITORS TMC-95A, DEPENDENT KINASE INHIBITORS, CIMICIFUGA-DAHURICA MAXIM, STEREOSELECTIVE-SYNTHESIS, OXINDOLE ALKALOIDS, SELECTIVE SYNTHESIS, CELL-CYCLE, 2-(ALKYNYL)ARYL ISOCYANATES
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