Abstract
Two mild and efficient strategies have been developed for the O-functionalisation of 4-hydroxy-6-alkyl-2-pyrones, by using them as nucleophilic partners in oxa-Michael additions and the Mitsunobu reaction. The reactions proceed in moderate to excellent yields on a range of substrates containing useful functionality. The reactions serve as practical and valuable synthetic methods to construct complex 2-pyronyl ethers, which are found embedded in a number of natural products.
Original language | English |
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Pages (from-to) | 1159-1165 |
Number of pages | 7 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 10 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- HETEROCYCLES
- Mitsonobu
- Oxa-Michael
- 2-PYRONES
- VINYL ETHERS