4-(Sulfonylamino)phenyl α-D-glucopyranosides as competitive inhibitors of yeast α-glucosidase

Josie C. Briggs, Alan H. Haines*, Richard J K Taylor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Certain members of a series of 4-(sulfonylamino)phenyl α-D- glucopyranosides are extremely good competitive inhibitors of yeast α-glucosidase and, remarkably, 4-(4-nitrophenylsulfonylamino)phenyl and 4-(2-naphthylsulfonylamino)phenyl α-D-glucopyranoside (Ki, 4.8 and 3.1 μmol dm-3, respectively) are superior to 1-deoxynojirimycin (Ki, 14.6 μmol dm-3) against this enzyme.

Original languageEnglish
Pages (from-to)1410-1411
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number18
Publication statusPublished - 1 Dec 1993

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