4-(Sulfonylamino)phenyl α-D-glucopyranosides as competitive inhibitors of yeast α-glucosidase

Josie C. Briggs; Alan H. Haines; Richard J K Taylor

doi:10.1039/C39930001410

4-(Sulfonylamino)phenyl α-D-glucopyranosides as competitive inhibitors of yeast α-glucosidase

Josie C. Briggs, Alan H. Haines^*, Richard J K Taylor

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Certain members of a series of 4-(sulfonylamino)phenyl α-D- glucopyranosides are extremely good competitive inhibitors of yeast α-glucosidase and, remarkably, 4-(4-nitrophenylsulfonylamino)phenyl and 4-(2-naphthylsulfonylamino)phenyl α-D-glucopyranoside (K_i, 4.8 and 3.1 μmol dm^-3, respectively) are superior to 1-deoxynojirimycin (K_i, 14.6 μmol dm^-3) against this enzyme.

Original language	English
Pages (from-to)	1410-1411
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	18
DOIs	https://doi.org/10.1039/C39930001410
Publication status	Published - 1 Dec 1993

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abstract = "Certain members of a series of 4-(sulfonylamino)phenyl α-D- glucopyranosides are extremely good competitive inhibitors of yeast α-glucosidase and, remarkably, 4-(4-nitrophenylsulfonylamino)phenyl and 4-(2-naphthylsulfonylamino)phenyl α-D-glucopyranoside (Ki, 4.8 and 3.1 μmol dm-3, respectively) are superior to 1-deoxynojirimycin (Ki, 14.6 μmol dm-3) against this enzyme.",

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T1 - 4-(Sulfonylamino)phenyl α-D-glucopyranosides as competitive inhibitors of yeast α-glucosidase

AU - Briggs, Josie C.

AU - Haines, Alan H.

AU - Taylor, Richard J K

PY - 1993/12/1

Y1 - 1993/12/1

N2 - Certain members of a series of 4-(sulfonylamino)phenyl α-D- glucopyranosides are extremely good competitive inhibitors of yeast α-glucosidase and, remarkably, 4-(4-nitrophenylsulfonylamino)phenyl and 4-(2-naphthylsulfonylamino)phenyl α-D-glucopyranoside (Ki, 4.8 and 3.1 μmol dm-3, respectively) are superior to 1-deoxynojirimycin (Ki, 14.6 μmol dm-3) against this enzyme.

AB - Certain members of a series of 4-(sulfonylamino)phenyl α-D- glucopyranosides are extremely good competitive inhibitors of yeast α-glucosidase and, remarkably, 4-(4-nitrophenylsulfonylamino)phenyl and 4-(2-naphthylsulfonylamino)phenyl α-D-glucopyranoside (Ki, 4.8 and 3.1 μmol dm-3, respectively) are superior to 1-deoxynojirimycin (Ki, 14.6 μmol dm-3) against this enzyme.

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U2 - 10.1039/C39930001410

DO - 10.1039/C39930001410

M3 - Article

AN - SCOPUS:0027443524

SN - 0022-4936

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EP - 1411

JO - JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS

JF - JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS

IS - 18

ER -

4-(Sulfonylamino)phenyl α-D-glucopyranosides as competitive inhibitors of yeast α-glucosidase

Abstract

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