4-(SULFONYLAMINO)PHENYL ALPHA-D-GLUCOPYRANOSIDES AS COMPETITIVE INHIBITORS OF YEAST ALPHA-GLUCOSIDASE

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Research output: Contribution to journal › Article

Author(s)

J C BRIGGS
A H HAINES
R J K TAYLOR

Department/unit(s)

Chemistry

Publication details

Journal	JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS
Date	Published - 21 Sep 1993
Issue number	18
Number of pages	2
Pages (from-to)	1410-1411
Original language	English

Abstract

Certain members of a series of 4-(sulfonylamino)phenyl alpha-D-glucopyranosides are extremely good competitive inhibitors of yeast alpha-glucosidase and, remarkably, 4-(4-nitrophenylsulfonylamino)phenyl and 4-(2-naphthylsulfonylamino)phenyl alpha-D-glucopyranoside (K(i) 4.8 and 3.1 mumol dm-3, respectively) are superior to 1-deoxynojirimycin (K(i) 14.6 mumol dm-3) against this enzyme.

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