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4-(Sulfonylamino)phenyl α-D-glucopyranosides as competitive inhibitors of yeast α-glucosidase
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| Journal | Journal of the Chemical Society, Chemical Communications |
|---|---|
| Date | Published - 1 Dec 1993 |
| Issue number | 18 |
| Number of pages | 2 |
| Pages (from-to) | 1410-1411 |
| Original language | English |
Abstract
Certain members of a series of 4-(sulfonylamino)phenyl α-D- glucopyranosides are extremely good competitive inhibitors of yeast α-glucosidase and, remarkably, 4-(4-nitrophenylsulfonylamino)phenyl and 4-(2-naphthylsulfonylamino)phenyl α-D-glucopyranoside (Ki, 4.8 and 3.1 μmol dm-3, respectively) are superior to 1-deoxynojirimycin (Ki, 14.6 μmol dm-3) against this enzyme.
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