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4-(Sulfonylamino)phenyl α-D-glucopyranosides as competitive inhibitors of yeast α-glucosidase

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JournalJournal of the Chemical Society, Chemical Communications
DatePublished - 1 Dec 1993
Issue number18
Number of pages2
Pages (from-to)1410-1411
Original languageEnglish

Abstract

Certain members of a series of 4-(sulfonylamino)phenyl α-D- glucopyranosides are extremely good competitive inhibitors of yeast α-glucosidase and, remarkably, 4-(4-nitrophenylsulfonylamino)phenyl and 4-(2-naphthylsulfonylamino)phenyl α-D-glucopyranoside (Ki, 4.8 and 3.1 μmol dm-3, respectively) are superior to 1-deoxynojirimycin (Ki, 14.6 μmol dm-3) against this enzyme.

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