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A case-control study of cancer of the uterine cervix in Uganda

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Author(s)

  • Robert Newton
  • John Ziegler
  • Delphine Casabonne
  • Valerie Beral
  • Edward Mbidde
  • Lucy Carpenter
  • D. Maxwell Parkin
  • Henry Wabinga
  • Sam Mbulaiteye
  • Harold Jaffe
  • Uganda Kaposi's Sarcoma Study Grp

Department/unit(s)

Publication details

JournalEuropean journal of cancer prevention
DatePublished - Dec 2007
Issue number6
Volume16
Number of pages4
Pages (from-to)555-558
Original languageEnglish

Abstract

As part of an epidemiological study of cancer in Uganda, we investigated social, sexual and reproductive factors in relation to the risk of cancer of the uterine cervix. Patients with all cancer types or with benign tumours were recruited from hospitals in Kampala, Uganda, interviewed about various demographic and lifestyle factors and tested for antibodies against the human immunodeficiency virus-1 (HIV). The case-control study reported here involves 702 HIV-seronegative women, 343 of whom were diagnosed with cancer of the uterine cervix. Key findings were that the risk of cervical cancer increased linearly with the number of pregnancies [chi(2)(1) = 44.7; P< 0.0001]; a woman reporting having had 10 or more children had a roughly seven-fold increase in risk of the tumour as compared with women reporting fewer than four pregnancies (odds ratio=7.1; 95% confidence interval 3.8-13.2). The risk also varied inversely with age at first reported sexual intercourse [chi(2)(1)=8.4; P=0.004], perhaps reflecting an earlier age of infection with human papillomavirus, the main causal agent. These results are in line with those reported from studies in other countries.

    Research areas

  • cervix cancer, Uganda, IMMUNODEFICIENCY-VIRUS-INFECTION, RISK-FACTORS, KAPOSIS-SARCOMA, HUMAN-PAPILLOMAVIRUS, SOUTH-AFRICA, CARCINOMA, HIV, WORLDWIDE, ADULTS, WOMEN

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