A coarse-grained model of the expansionof the human rhinovirus 2 capsid revealsinsights in genome release

TY - JOUR

T1 - A coarse-grained model of the expansionof the human rhinovirus 2 capsid revealsinsights in genome release

AU - Indelicato, Giuliana

AU - Cermelli, Paolo

AU - Twarock, Reidun

PY - 2019/8/14

Y1 - 2019/8/14

N2 - Human rhinoviruses are causative agents of the common cold. In order torelease their RNA genome into the host during a viral infection, these smallviruses must undergo conformational changes in their capsids, whosedetailed mechanism is strictly related to the process of RNA extrusion,which has been only partially elucidated. We study here a mathematicalmodel for the structural transition between the native particle of human rhi-novirus type 2 and its expanded form, viewing the process as an energycascade, i.e. a sequence of metastable states with decreasing energy connectedby minimum energy paths. We explore several transition pathways anddiscuss their implications for the RNA exit process

AB - Human rhinoviruses are causative agents of the common cold. In order torelease their RNA genome into the host during a viral infection, these smallviruses must undergo conformational changes in their capsids, whosedetailed mechanism is strictly related to the process of RNA extrusion,which has been only partially elucidated. We study here a mathematicalmodel for the structural transition between the native particle of human rhi-novirus type 2 and its expanded form, viewing the process as an energycascade, i.e. a sequence of metastable states with decreasing energy connectedby minimum energy paths. We explore several transition pathways anddiscuss their implications for the RNA exit process

KW - minimum energy paths

KW - energy landscape

KW - viral structuraltransitions

U2 - 10.1098/rsif.2019.0044

DO - 10.1098/rsif.2019.0044

M3 - Article

SN - 1742-5689

VL - 16

JO - Journal of the Royal Society Interface

JF - Journal of the Royal Society Interface

IS - 157

M1 - 20190044

ER -