Sodium density maps acquired with three SPRITE-based methods have been compared in terms of the resulting quantitative information as well as image quality and acquisition times. Consideration of factors relevant for the clinical implementation of SPRITE shows that the Conical-SPRITE variant is preferred because of a 20-fold reduction in acquisition time, slightly improved image quality, and no loss of quantitative information. The acquisition of a 3D data set (32 × 32 × 16; FOV = 256 × 256 × 160 mm) for the quantitative determination of sodium density is demonstrated. In vivo Conical-SPRITE Na images of the brain of a healthy volunteer were acquired in 30 min with a resolution of 7.5 × 7.5 × 7.5 mm and a signal-to-noise ratio of 23 in cerebrospinal fluid and 17 in brain tissue.
- Quadrupolar interaction