A consecutive ring expansion strategy towards the macrocyclic core of the solomonamide natural products

Zhongzhen Yang, Christopher R.B. Swanson, William Paul Unsworth*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A synthetic strategy based on the application of three consecutive ring expansion reactions has been used in the synthesis of analogues of the macrocyclic core of the solomonamide natural products. Starting from a simple, readily available tetrahydrocarbazole, oxidative ring expansion is followed by two further 3-and 4-atom ring expansion reactions, enabling the insertion of amino acid-and hydroxyacid-derived linear fragments into 15-17-membered ring-enlarged macrocyclic products.

Original languageEnglish
Number of pages5
Early online date30 Sept 2022
Publication statusE-pub ahead of print - 30 Sept 2022

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© 2022 Georg Thieme Verlag. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details


  • Lactams
  • Lactones
  • Macrocycles
  • Medium-sized rings
  • Natural product analogues
  • Ring expansion
  • Solomonamides

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