A convergent synthesis of the tricyclic core of the dictyosphaeric acids

Christopher W. Barfoot, Alan R. Burns, Michael G. Edwards, Martin N. Kenworthy, Mahmood Ahmed, Stephen E. Shanahan, Richard J. K. Taylor

Research output: Contribution to journalArticlepeer-review

Abstract

The first synthetic route to the tricyclic core of the dictyosphaeric acids has been established starting from readily available (S)-(-)-4-(tert-butyldimethylsilyloxy)cyclohexenone and involving 9 steps, including a ring-closing metathesis to produce a 13-membered macrolactone, and a doubly tethered intramolecular Michael addition.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalOrganic Letters
Volume10
Issue number2
DOIs
Publication statusPublished - 17 Jan 2008

Keywords

  • MICHAEL REACTION
  • 4-HYDROXYCYCLOHEX-2-ENONE

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