Abstract
A facile copper(II)-mediated C-H bond oxidation and C-C bond formation procedure has been applied to the synthesis of indole derivatives. Intramolecular oxidative coupling of 3,3-disubstituted enamines proceeded using a non-expensive and air-stable copper salt, Cu(2-ethylhexanoate)2, to afford the corresponding C-3 quaternary indolenine products in good to excellent yields. 1H-Indoles can be prepared in a similar manner but in this case, Cu(OAc)2·H2O has been found to be the preferred oxidant.
Original language | English |
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Pages (from-to) | 2333-2336 |
Number of pages | 4 |
Journal | European Journal of Organic Chemistry |
Volume | 2015 |
Issue number | 11 |
Early online date | 13 Mar 2015 |
DOIs | |
Publication status | Published - Apr 2015 |
Keywords
- 1H-Indole
- 3H-Indole
- Copper-mediated coupling
- Cyclization
- Heterocycles