A copper(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination approach to 2-quinolones

Ryan M. Gorman, Timothy E. Hurst, Wade F. Petersen, Richard J.K. Taylor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A new cyclisation procedure to prepare 4-carboxy-quinolin-2-ones via a one-pot Cu(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination of linear anilides is described. Extensions to more complex substrates are also reported as are applications in target synthesis allowing access to natural products isolated from Oryza sativa and HOFQ.

Original languageEnglish
Article number130711
Issue number49
Early online date21 Oct 2019
Publication statusE-pub ahead of print - 21 Oct 2019

Bibliographical note

© 2019 Elsevier Ltd. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy.


  • 2-Quinolones
  • Cross-dehydrogenative coupling
  • Cu(II)-catalysis
  • Total synthesis

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