A copper(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination approach to 2-quinolones

TY - JOUR

T1 - A copper(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination approach to 2-quinolones

AU - Gorman, Ryan M.

AU - Hurst, Timothy E.

AU - Petersen, Wade F.

AU - Taylor, Richard J.K.

N1 - © 2019 Elsevier Ltd. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy.

PY - 2019/10/21

Y1 - 2019/10/21

N2 - A new cyclisation procedure to prepare 4-carboxy-quinolin-2-ones via a one-pot Cu(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination of linear anilides is described. Extensions to more complex substrates are also reported as are applications in target synthesis allowing access to natural products isolated from Oryza sativa and HOFQ.

AB - A new cyclisation procedure to prepare 4-carboxy-quinolin-2-ones via a one-pot Cu(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination of linear anilides is described. Extensions to more complex substrates are also reported as are applications in target synthesis allowing access to natural products isolated from Oryza sativa and HOFQ.

KW - 2-Quinolones

KW - Cross-dehydrogenative coupling

KW - Cu(II)-catalysis

KW - Total synthesis

UR - http://www.scopus.com/inward/record.url?scp=85074889413&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2019.130711

DO - 10.1016/j.tet.2019.130711

M3 - Article

AN - SCOPUS:85074889413

SN - 0040-4020

VL - 75

JO - Tetrahedron

JF - Tetrahedron

IS - 49

M1 - 130711

ER -