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Research output: Contribution to journal › Article

Published copy (DOI)

10.1002/ejoc.201500112

Author(s)

Pauline Drouhin
Richard J. K. Taylor

Department/unit(s)

Publication details

Journal	European Journal of Organic Chemistry
Date	E-pub ahead of print - 13 Mar 2015
Date	Published (current) - Apr 2015
Issue number	11
Volume	2015
Number of pages	4
Pages (from-to)	2333-2336
Early online date	13/03/15
Original language	English

Abstract

A facile copper(II)-mediated C-H bond oxidation and C-C bond formation procedure has been applied to the synthesis of indole derivatives. Intramolecular oxidative coupling of 3,3-disubstituted enamines proceeded using a non-expensive and air-stable copper salt, Cu(2-ethylhexanoate)₂, to afford the corresponding C-3 quaternary indolenine products in good to excellent yields. 1H-Indoles can be prepared in a similar manner but in this case, Cu(OAc)₂·H₂O has been found to be the preferred oxidant.

Research areas

1H-Indole, 3H-Indole, Copper-mediated coupling, Cyclization, Heterocycles

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