Projects per year
Abstract
Background
People with severe mental illness (SMI), such as schizophrenia, have higher rates of type 2 diabetes and worse outcomes, compared to those without SMI and it is not known whether diabetes self-management interventions are effective for people who have both conditions. Research in this area has been impeded by a lack of consensus on which outcomes to prioritise in people with co-existing SMI and diabetes.
Aims
To develop a core outcome set (COS) for use in effectiveness trials of diabetes self-management interventions in adults with both type 2 diabetes and SMI.
Methods
The COS was developed in three stages: (i) identification of outcomes from systematic literature review of intervention studies, followed by multi-stakeholder and service user workshops; (ii) rating of outcomes in a two-round online Delphi survey; (iii) agreement of final ‘core’ outcomes through a stakeholder consensus workshop.
Results
Seven outcomes were selected: glucose control, blood pressure, body composition (body weight, BMI, body fat), health-related quality of life, diabetes self-management, diabetes-related distress and medication adherence.
Conclusions
This COS is recommended for future trials of effectiveness of diabetes self-management interventions for people with SMI and type 2 diabetes. Its use will ensure trials capture important outcomes and reduce heterogeneity so findings can be readily synthesised to inform practice and policy.
People with severe mental illness (SMI), such as schizophrenia, have higher rates of type 2 diabetes and worse outcomes, compared to those without SMI and it is not known whether diabetes self-management interventions are effective for people who have both conditions. Research in this area has been impeded by a lack of consensus on which outcomes to prioritise in people with co-existing SMI and diabetes.
Aims
To develop a core outcome set (COS) for use in effectiveness trials of diabetes self-management interventions in adults with both type 2 diabetes and SMI.
Methods
The COS was developed in three stages: (i) identification of outcomes from systematic literature review of intervention studies, followed by multi-stakeholder and service user workshops; (ii) rating of outcomes in a two-round online Delphi survey; (iii) agreement of final ‘core’ outcomes through a stakeholder consensus workshop.
Results
Seven outcomes were selected: glucose control, blood pressure, body composition (body weight, BMI, body fat), health-related quality of life, diabetes self-management, diabetes-related distress and medication adherence.
Conclusions
This COS is recommended for future trials of effectiveness of diabetes self-management interventions for people with SMI and type 2 diabetes. Its use will ensure trials capture important outcomes and reduce heterogeneity so findings can be readily synthesised to inform practice and policy.
| Original language | English |
|---|---|
| Article number | e15288 |
| Number of pages | 10 |
| Journal | Diabetic Medicine |
| Early online date | 18 Jan 2024 |
| DOIs | |
| Publication status | E-pub ahead of print - 18 Jan 2024 |
Bibliographical note
© 2024 The Authors.Keywords
- Type 2 diabetes mellitus
- severe mental illness
- core outcome set
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NIHR Programme Grant: DIAMONDS - Developing and evaluating a diabetes self-management education intervention for people with severe mental illness.
Siddiqi, N. (Principal investigator), Ali, S. (Co-investigator), Boehnke, J. R. (Co-investigator), Coventry, P. (Co-investigator), Doherty, P. J. (Co-investigator), Gilbody, S. (Co-investigator), Hewitt, C. E. (Co-investigator), Parrott, S. (Co-investigator), Taylor, J. (Co-investigator) & Watson, J. (Co-investigator)
1/05/18 → 30/11/25
Project: Research project (funded) › Research
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NIHR Programme Development Grant: DIAMONDS - Developing and evaluating a diabetes self-management education intervention for people with severe mental illness:
Siddiqi, N. (Principal investigator), Ali, S. (Co-investigator), Doran, T. (Co-investigator), Gilbody, S. (Co-investigator), Hewitt, C. E. (Co-investigator), Lewis, H. J. (Co-investigator), Parrott, S. (Co-investigator) & Taylor, J. (Co-investigator)
1/02/16 → 31/01/17
Project: Research project (funded) › Research