A critical appraisal of pharmacoeconomic studies comparing TNFα antagonists for the treatment of rheumatoid arthritis

M. Barbieri; M. Drummond; J. Puig Junoy; M.A. Casado Gómez; F.J. Ballina García; P. Blasco Segura; J.L. Poveda Andrés

A critical appraisal of pharmacoeconomic studies comparing TNFα antagonists for the treatment of rheumatoid arthritis

M. Barbieri, M. Drummond, J. Puig Junoy, M.A. Casado Gómez, F.J. Ballina García, P. Blasco Segura, J.L. Poveda Andrés

Centre for Health Economics

Research output: Contribution to journal › Article › peer-review

Abstract

Clinical trials and economic models have showed that anti-TNF agents are effective and cost-effective compared to standard therapies (mainly DMARDs) in patients with RA. However, no head-to-head clinical trials between these agents are available and the relative effectiveness and cost-effectiveness is uncertain. We have conducted a literature review in order to identify full economic evaluations that compared two or more TNF antagonists. A description of each study was given and key methodological issues identified. These included methods for evidence synthesis, model characteristics and methods to address uncertainty in model parameters. Important differences in methodological features and results have been found between studies. More attention in future studies should be given to methods for indirect comparisons between the biological agents.

Original language	Undefined/Unknown
Pages (from-to)	613-626
Number of pages	14
Journal	Expert Review of Pharmacoeconomics and Outcomes Research
Volume	7
Issue number	6
Publication status	Published - 2007

Keywords

cost-effectiveness, anti-TNF, critical appraisal, models, indirect comparisons, rheumatoid arthritis

Cite this

@article{34f6aa73779f40d6bbada97d4ed394dd,

title = "A critical appraisal of pharmacoeconomic studies comparing TNFα antagonists for the treatment of rheumatoid arthritis",

abstract = "Clinical trials and economic models have showed that anti-TNF agents are effective and cost-effective compared to standard therapies (mainly DMARDs) in patients with RA. However, no head-to-head clinical trials between these agents are available and the relative effectiveness and cost-effectiveness is uncertain. We have conducted a literature review in order to identify full economic evaluations that compared two or more TNF antagonists. A description of each study was given and key methodological issues identified. These included methods for evidence synthesis, model characteristics and methods to address uncertainty in model parameters. Important differences in methodological features and results have been found between studies. More attention in future studies should be given to methods for indirect comparisons between the biological agents.",

keywords = "cost-effectiveness, anti-TNF, critical appraisal, models, indirect comparisons, rheumatoid arthritis",

author = "M. Barbieri and M. Drummond and {Puig Junoy}, J. and {Casado G{\'o}mez}, M.A. and {Ballina Garc{\'i}a}, F.J. and {Blasco Segura}, P. and {Poveda Andr{\'e}s}, J.L.",

year = "2007",

language = "Undefined/Unknown",

volume = "7",

pages = "613--626",

journal = "Expert Review of Pharmacoeconomics and Outcomes Research",

issn = "1744-8379",

publisher = "Expert Reviews Ltd.",

number = "6",

}

TY - JOUR

T1 - A critical appraisal of pharmacoeconomic studies comparing TNFα antagonists for the treatment of rheumatoid arthritis

AU - Barbieri, M.

AU - Drummond, M.

AU - Puig Junoy, J.

AU - Casado Gómez, M.A.

AU - Ballina García, F.J.

AU - Blasco Segura, P.

AU - Poveda Andrés, J.L.

PY - 2007

Y1 - 2007

N2 - Clinical trials and economic models have showed that anti-TNF agents are effective and cost-effective compared to standard therapies (mainly DMARDs) in patients with RA. However, no head-to-head clinical trials between these agents are available and the relative effectiveness and cost-effectiveness is uncertain. We have conducted a literature review in order to identify full economic evaluations that compared two or more TNF antagonists. A description of each study was given and key methodological issues identified. These included methods for evidence synthesis, model characteristics and methods to address uncertainty in model parameters. Important differences in methodological features and results have been found between studies. More attention in future studies should be given to methods for indirect comparisons between the biological agents.

AB - Clinical trials and economic models have showed that anti-TNF agents are effective and cost-effective compared to standard therapies (mainly DMARDs) in patients with RA. However, no head-to-head clinical trials between these agents are available and the relative effectiveness and cost-effectiveness is uncertain. We have conducted a literature review in order to identify full economic evaluations that compared two or more TNF antagonists. A description of each study was given and key methodological issues identified. These included methods for evidence synthesis, model characteristics and methods to address uncertainty in model parameters. Important differences in methodological features and results have been found between studies. More attention in future studies should be given to methods for indirect comparisons between the biological agents.

KW - cost-effectiveness, anti-TNF, critical appraisal, models, indirect comparisons, rheumatoid arthritis

M3 - Article

SN - 1744-8379

VL - 7

SP - 613

EP - 626

JO - Expert Review of Pharmacoeconomics and Outcomes Research

JF - Expert Review of Pharmacoeconomics and Outcomes Research

IS - 6

ER -