A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles

Timothy E. Hurst*, Richard J.K. Taylor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The synthesis of acridanes and related compounds through a Cu-catalysed radical cross-dehydrogenative coupling of simple 2-[2-(arylamino)aryl]malonates is reported. This method can be further streamlined to a one-pot protocol involving the in situ fomation of the 2-[2-(arylamino)aryl]malonate by α-arylation of diethyl malonate with 2-bromodiarylamines under Pd catalysis, followed by Cu-catalysed cyclisation.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalEuropean Journal of Organic Chemistry
Issue number1
Publication statusPublished - 3 Jan 2017

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© 2017 Wiley-VCH Verlag GmbH & Co. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details


  • Acridanes
  • Copper
  • Cross-coupling
  • Dehydrogenation
  • Homogeneous catalysis
  • Nitrogen heterocycles
  • One-pot reaction

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