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A dendritic active site: Catalysis of the Henry reaction

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Publication details

JournalOrganic Letters
DatePublished - 4 Oct 2001
Issue number20
Volume3
Number of pages4
Pages (from-to)3075-3078
Original languageEnglish

Abstract

[GRAPHICS]

Dendrimers containing an encapsulated tertiary amine were prepared by coupling tris(2-aminoethyl)amine with dendritic branches derived from L-lysine. These dendrimers were used as catalysts in the Henry (nitroaldol) reaction between 4-nitrobenzaidehyde and nitroethane, and their catalytic performance was compared with that of triethylamine. Attachment of the dendritic shell alters the rate of reaction and influences the syn:anti ratio of products. It is proposed that the dendritic shell generates an encapsulated catalytically active site, mimicking the behavior of a protein superstructure.

    Research areas

  • MEMBRANE REACTOR, ENANTIOSELECTIVE CATALYSIS, CARBOSILANE DENDRIMERS, LIGANDS, COMPLEXES, PROBE

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