By the same authors

From the same journal

A different path: Revealing the function of staphylococcal proteins in biofilm formation.

Research output: Contribution to journalArticle

Standard

A different path : Revealing the function of staphylococcal proteins in biofilm formation. / Atkin, Kate Elizabeth; MacDonald, Sandy; Brentnall, Andrew Stephen; Potts, Jennifer Robyn; Thomas, Gavin Hugh.

In: FEBS Letters, Vol. 588, No. 10, 21.05.2014, p. 1869-1872.

Research output: Contribution to journalArticle

Harvard

Atkin, KE, MacDonald, S, Brentnall, AS, Potts, JR & Thomas, GH 2014, 'A different path: Revealing the function of staphylococcal proteins in biofilm formation.', FEBS Letters, vol. 588, no. 10, pp. 1869-1872. https://doi.org/10.1016/j.febslet.2014.04.002

APA

Atkin, K. E., MacDonald, S., Brentnall, A. S., Potts, J. R., & Thomas, G. H. (2014). A different path: Revealing the function of staphylococcal proteins in biofilm formation. FEBS Letters, 588(10), 1869-1872. https://doi.org/10.1016/j.febslet.2014.04.002

Vancouver

Atkin KE, MacDonald S, Brentnall AS, Potts JR, Thomas GH. A different path: Revealing the function of staphylococcal proteins in biofilm formation. FEBS Letters. 2014 May 21;588(10):1869-1872. https://doi.org/10.1016/j.febslet.2014.04.002

Author

Atkin, Kate Elizabeth ; MacDonald, Sandy ; Brentnall, Andrew Stephen ; Potts, Jennifer Robyn ; Thomas, Gavin Hugh. / A different path : Revealing the function of staphylococcal proteins in biofilm formation. In: FEBS Letters. 2014 ; Vol. 588, No. 10. pp. 1869-1872.

Bibtex - Download

@article{e27b0c15c77e43348f373d43a84c2899,
title = "A different path: Revealing the function of staphylococcal proteins in biofilm formation.",
abstract = "Staphylococcus aureus and Staphylococcus epidermidis cause dangerous and difficult to treat medical device-related infections through their ability to form biofilms. Extracellular poly-N-acetylglucosamine (PNAG) facilitates biofilm formation and is a vaccination target, yet details of its biosynthesis by the icaADBC gene products is limited. IcaC is the proposed transporter for PNAG export, however a comparison of the Ica proteins to homologous exo-polysaccharide synthases suggests that the common IcaAD protein components both synthesise and transport the PNAG. The limited distribution of icaC to the Staphylococcaceae and its membership of a family of membrane-bound acyltransferases, leads us to suggest that IcaC is responsible for the known O-succinylation of PNAG that occurs in staphylococci, identifying a potentially new therapeutic target specific for these bacteria.",
author = "Atkin, {Kate Elizabeth} and Sandy MacDonald and Brentnall, {Andrew Stephen} and Potts, {Jennifer Robyn} and Thomas, {Gavin Hugh}",
year = "2014",
month = "5",
day = "21",
doi = "10.1016/j.febslet.2014.04.002",
language = "English",
volume = "588",
pages = "1869--1872",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "10",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A different path

T2 - Revealing the function of staphylococcal proteins in biofilm formation.

AU - Atkin, Kate Elizabeth

AU - MacDonald, Sandy

AU - Brentnall, Andrew Stephen

AU - Potts, Jennifer Robyn

AU - Thomas, Gavin Hugh

PY - 2014/5/21

Y1 - 2014/5/21

N2 - Staphylococcus aureus and Staphylococcus epidermidis cause dangerous and difficult to treat medical device-related infections through their ability to form biofilms. Extracellular poly-N-acetylglucosamine (PNAG) facilitates biofilm formation and is a vaccination target, yet details of its biosynthesis by the icaADBC gene products is limited. IcaC is the proposed transporter for PNAG export, however a comparison of the Ica proteins to homologous exo-polysaccharide synthases suggests that the common IcaAD protein components both synthesise and transport the PNAG. The limited distribution of icaC to the Staphylococcaceae and its membership of a family of membrane-bound acyltransferases, leads us to suggest that IcaC is responsible for the known O-succinylation of PNAG that occurs in staphylococci, identifying a potentially new therapeutic target specific for these bacteria.

AB - Staphylococcus aureus and Staphylococcus epidermidis cause dangerous and difficult to treat medical device-related infections through their ability to form biofilms. Extracellular poly-N-acetylglucosamine (PNAG) facilitates biofilm formation and is a vaccination target, yet details of its biosynthesis by the icaADBC gene products is limited. IcaC is the proposed transporter for PNAG export, however a comparison of the Ica proteins to homologous exo-polysaccharide synthases suggests that the common IcaAD protein components both synthesise and transport the PNAG. The limited distribution of icaC to the Staphylococcaceae and its membership of a family of membrane-bound acyltransferases, leads us to suggest that IcaC is responsible for the known O-succinylation of PNAG that occurs in staphylococci, identifying a potentially new therapeutic target specific for these bacteria.

U2 - 10.1016/j.febslet.2014.04.002

DO - 10.1016/j.febslet.2014.04.002

M3 - Article

VL - 588

SP - 1869

EP - 1872

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 10

ER -