A direct C-H/Ar-H coupling approach to oxindoles, thio-oxindoles, 3,4-dihydro-1H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines

Timothy Edgar Hurst, Ryan Michael Gorman, Pauline Drouhin, Alexis Perry, Richard John Kenneth Taylor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A copper(II)-catalysed approach to oxindoles, thio-oxindoles, 3,4-dihydro-1H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines via formal C-H, Ar-H coupling is described. In a new variant, copper(II) 2-ethylhexanoate has been identified as an inexpensive and efficient catalyst for this transformation, which utilises atmospheric oxygen as the re-oxidant.

Original languageEnglish
Pages (from-to)14063-14073
Number of pages11
JournalChemistry : A European Journal (Weinheim an der Bergstrasse, Germany)
Volume20
Issue number43
Early online date11 Sep 2014
DOIs
Publication statusPublished - 20 Oct 2014

Bibliographical note

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

  • Catalysis
  • Copper
  • Dihydroquinolinones
  • Oxindoles
  • Tetrahydroquinolines

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