A dynamic nuclear polarization strategy for multi-dimensional Earth's field NMR spectroscopy

Meghan E. Halse; Paul T. Callaghan

doi:10.1016/j.jmr.2008.09.007

A dynamic nuclear polarization strategy for multi-dimensional Earth's field NMR spectroscopy

Meghan E. Halse, Paul T. Callaghan

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Dynamic nuclear polarization (DNP) is introduced as a powerful tool for polarization enhancement in multi-dimensional Earth's field NMR spectroscopy. Maximum polarization enhancements, relative to thermal equilibrium in the Earth's magnetic field, are calculated theoretically and compared to the more traditional prepolarization approach for NMR sensitivity enhancement at ultra-low fields. Signal enhancement factors on the order of 3000 are demonstrated experimentally using DNP with a nitroxide free radical, TEMPO, which contains an unpaired electron which is strongly coupled to a neighboring N nucleus via the hyperfine interaction. A high-quality 2D F-H COSY spectrum acquired in the Earth's magnetic field with DNP enhancement is presented and compared to simulation.

Original language	English
Pages (from-to)	162-168
Number of pages	7
Journal	Journal of Magnetic Resonance
Volume	195
Issue number	2
Early online date	17 Sept 2008
DOIs	https://doi.org/10.1016/j.jmr.2008.09.007
Publication status	Published - Dec 2008

Keywords

Earth's magnetic field
Dynamic nuclear polarization
Sensitivity enhancement
Multi-dimensional spectroscopy
Nuclear magnetic resonance

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10.1016/j.jmr.2008.09.007

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title = "A dynamic nuclear polarization strategy for multi-dimensional Earth's field NMR spectroscopy",

abstract = "Dynamic nuclear polarization (DNP) is introduced as a powerful tool for polarization enhancement in multi-dimensional Earth's field NMR spectroscopy. Maximum polarization enhancements, relative to thermal equilibrium in the Earth's magnetic field, are calculated theoretically and compared to the more traditional prepolarization approach for NMR sensitivity enhancement at ultra-low fields. Signal enhancement factors on the order of 3000 are demonstrated experimentally using DNP with a nitroxide free radical, TEMPO, which contains an unpaired electron which is strongly coupled to a neighboring N nucleus via the hyperfine interaction. A high-quality 2D F-H COSY spectrum acquired in the Earth's magnetic field with DNP enhancement is presented and compared to simulation.",

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AU - Callaghan, Paul T.

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AB - Dynamic nuclear polarization (DNP) is introduced as a powerful tool for polarization enhancement in multi-dimensional Earth's field NMR spectroscopy. Maximum polarization enhancements, relative to thermal equilibrium in the Earth's magnetic field, are calculated theoretically and compared to the more traditional prepolarization approach for NMR sensitivity enhancement at ultra-low fields. Signal enhancement factors on the order of 3000 are demonstrated experimentally using DNP with a nitroxide free radical, TEMPO, which contains an unpaired electron which is strongly coupled to a neighboring N nucleus via the hyperfine interaction. A high-quality 2D F-H COSY spectrum acquired in the Earth's magnetic field with DNP enhancement is presented and compared to simulation.

KW - Earth's magnetic field

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A dynamic nuclear polarization strategy for multi-dimensional Earth's field NMR spectroscopy

Abstract

Keywords

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