A family of dual-activity glycosyltransferasesphosphorylases mediates mannogen turnover and virulence in Leishmania parasites

M. Fleur Sernee; Julie E. Ralton; Tracy L. Nero; Lukasz F. Sobala; Joachim Kloehn; Marcel Viera-Lara; Simon A. Cobbold; Lauren Stanton; Douglas E.V. Pires; Eric Hanssen; Alexandra Males; Tom Ward; Laurence M. Bastidas; Phillip L. van der Peet; Michael W. Parker; David B. Ascher; Spencer J. Williams; Gideon J Davies; Malcolm J. McConville

doi:10.1016/j.chom.2019.08.009

A family of dual-activity glycosyltransferasesphosphorylases mediates mannogen turnover and virulence in Leishmania parasites

M. Fleur Sernee, Julie E. Ralton, Tracy L. Nero, Lukasz F. Sobala, Joachim Kloehn, Marcel Viera-Lara, Simon A. Cobbold, Lauren Stanton, Douglas E.V. Pires, Eric Hanssen, Alexandra Males, Tom Ward, Laurence M. Bastidas, Phillip L. van der Peet, Michael W. Parker, David B. Ascher, Spencer J. Williams, Gideon J Davies, Malcolm J. McConville

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	385-399
Number of pages	15
Journal	Cell Host & Microbe
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2019.08.009
Publication status	Published - 11 Sept 2019

Bibliographical note

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10.1016/j.chom.2019.08.009

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnoverand Virulence inLeishmaniaParasites
© 2019 The Authors
Final published version, 6.08 MBLicence: CC BY

White Rose Doctoral Training Partnership in Mechanistic Biology and its Strategic Application
Pownall, B. (Principal investigator)
1/10/15 → 30/09/23
Project: Research project (funded) › Studentship (central)
Glycosylation: Programmes for Observation, Inhibition & Structure-based Exploitation of key carbohydrate-active enzymes
Davies, G. J. (Principal investigator)
EUROPEAN COMMISSION
1/05/13 → 30/04/19
Project: Research project (funded) › Research

Diffraction images used to solve the structures published in the article "A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites"
Sobala, Ł. F. (Creator), Males, A. (Creator), Davies, G. J. (Creator), Sernee, M. F. (Contributor), Ralton, J. E. (Contributor), Nero, T. L. (Contributor), Kloehn, J. (Contributor), Vieira-Lara, M. A. (Contributor), Cobbold, S. A. (Contributor), Stanton, L. (Contributor), Pires, D. E. V. (Contributor), Hanssen, E. (Contributor), Ward, T. (Contributor), M. Bastidas, L. (Contributor), van der Peet, P. L. (Contributor), Parker, M. W. (Contributor), Ascher, D. B. (Contributor), Williams, S. J. (Contributor) & McConville, M. J. (Contributor), Zenodo, 2 Feb 2021
DOI: 10.5281/zenodo.4428651
Dataset

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Sernee, M. F., Ralton, J. E., Nero, T. L., Sobala, L. F., Kloehn, J., Viera-Lara, M., Cobbold, S. A., Stanton, L., Pires, D. E. V., Hanssen, E., Males, A., Ward, T., Bastidas, L. M., Peet, P. L. V. D., Parker, M. W., Ascher, D. B., Williams, S. J., Davies, G. J., & McConville, M. J. (2019). A family of dual-activity glycosyltransferasesphosphorylases mediates mannogen turnover and virulence in Leishmania parasites. Cell Host & Microbe, 26(3), 385-399. https://doi.org/10.1016/j.chom.2019.08.009

@article{50824079831d42d38d9d500b95c0792e,

title = "A family of dual-activity glycosyltransferasesphosphorylases mediates mannogen turnover and virulence in Leishmania parasites",

author = "Sernee, {M. Fleur} and Ralton, {Julie E.} and Nero, {Tracy L.} and Sobala, {Lukasz F.} and Joachim Kloehn and Marcel Viera-Lara and Cobbold, {Simon A.} and Lauren Stanton and Pires, {Douglas E.V.} and Eric Hanssen and Alexandra Males and Tom Ward and Bastidas, {Laurence M.} and Peet, {Phillip L. van der} and Parker, {Michael W.} and Ascher, {David B.} and Williams, {Spencer J.} and Davies, {Gideon J} and McConville, {Malcolm J.}",

note = "{\textcopyright} 2019 The Authors",

year = "2019",

month = sep,

day = "11",

doi = "10.1016/j.chom.2019.08.009",

language = "English",

volume = "26",

pages = "385--399",

journal = "Cell Host & Microbe",

issn = "1931-3128",

publisher = "Cell Press",

number = "3",

}

Sernee, MF, Ralton, JE, Nero, TL, Sobala, LF, Kloehn, J, Viera-Lara, M, Cobbold, SA, Stanton, L, Pires, DEV, Hanssen, E, Males, A, Ward, T, Bastidas, LM, Peet, PLVD, Parker, MW, Ascher, DB, Williams, SJ, Davies, GJ & McConville, MJ 2019, 'A family of dual-activity glycosyltransferasesphosphorylases mediates mannogen turnover and virulence in Leishmania parasites', Cell Host & Microbe, vol. 26, no. 3, pp. 385-399. https://doi.org/10.1016/j.chom.2019.08.009

TY - JOUR

T1 - A family of dual-activity glycosyltransferasesphosphorylases mediates mannogen turnover and virulence in Leishmania parasites

AU - Sernee, M. Fleur

AU - Ralton, Julie E.

AU - Nero, Tracy L.

AU - Sobala, Lukasz F.

AU - Kloehn, Joachim

AU - Viera-Lara, Marcel

AU - Cobbold, Simon A.

AU - Stanton, Lauren

AU - Pires, Douglas E.V.

AU - Hanssen, Eric

AU - Males, Alexandra

AU - Ward, Tom

AU - Bastidas, Laurence M.

AU - Peet, Phillip L. van der

AU - Parker, Michael W.

AU - Ascher, David B.

AU - Williams, Spencer J.

AU - Davies, Gideon J

AU - McConville, Malcolm J.

PY - 2019/9/11

Y1 - 2019/9/11

U2 - 10.1016/j.chom.2019.08.009

DO - 10.1016/j.chom.2019.08.009

M3 - Article

SN - 1931-3128

VL - 26

SP - 385

EP - 399

JO - Cell Host & Microbe

JF - Cell Host & Microbe

IS - 3

ER -

A family of dual-activity glycosyltransferasesphosphorylases mediates mannogen turnover and virulence in Leishmania parasites

Bibliographical note

Access to Document

Projects

White Rose Doctoral Training Partnership in Mechanistic Biology and its Strategic Application

Glycosylation: Programmes for Observation, Inhibition & Structure-based Exploitation of key carbohydrate-active enzymes

Datasets

Diffraction images used to solve the structures published in the article "A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites"

Cite this