A general method for obtaining calix[4]arene derivatives in the 1,2-alternate conformation

Petr Slavík, Václav Eigner, Pavel Lhoták*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The 1,2-alternate conformation, so far the least accessible atropisomer of calix[4]arene, is now easily available on a gram scale. The entire synthetic sequence consists of only two steps—(a) proximal dialkylation (R1-I, NaH/DMF), and (b) another subsequent dialkylation (R2-I, Me3SiOK/THF). The selection of appropriate base/solvent combinations in both stages was the key prerequisite for the successful preparation of the 1,2-alternate conformers, which are available without the use of any protecting groups.

Original languageEnglish
Pages (from-to)6348-6355
Number of pages8
Issue number41
Early online date13 Aug 2016
Publication statusPublished - 13 Oct 2016


  • 1,2-Alternate
  • Alkylation
  • Calixarene
  • Conformation
  • Conformational mobility
  • Partial cone

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