Research output: Contribution to journal › Article › peer-review
Journal | Tetrahedron |
---|---|
Date | Accepted/In press - 9 Aug 2016 |
Date | E-pub ahead of print - 13 Aug 2016 |
Date | Published (current) - 13 Oct 2016 |
Issue number | 41 |
Volume | 72 |
Number of pages | 8 |
Pages (from-to) | 6348-6355 |
Early online date | 13/08/16 |
Original language | English |
The 1,2-alternate conformation, so far the least accessible atropisomer of calix[4]arene, is now easily available on a gram scale. The entire synthetic sequence consists of only two steps—(a) proximal dialkylation (R1-I, NaH/DMF), and (b) another subsequent dialkylation (R2-I, Me3SiOK/THF). The selection of appropriate base/solvent combinations in both stages was the key prerequisite for the successful preparation of the 1,2-alternate conformers, which are available without the use of any protecting groups.
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