By the same authors

From the same journal

From the same journal

A general method for obtaining calix[4]arene derivatives in the 1,2-alternate conformation

Research output: Contribution to journalArticlepeer-review

Published copy (DOI)



Publication details

DateAccepted/In press - 9 Aug 2016
DateE-pub ahead of print - 13 Aug 2016
DatePublished (current) - 13 Oct 2016
Issue number41
Number of pages8
Pages (from-to)6348-6355
Early online date13/08/16
Original languageEnglish


The 1,2-alternate conformation, so far the least accessible atropisomer of calix[4]arene, is now easily available on a gram scale. The entire synthetic sequence consists of only two steps—(a) proximal dialkylation (R1-I, NaH/DMF), and (b) another subsequent dialkylation (R2-I, Me3SiOK/THF). The selection of appropriate base/solvent combinations in both stages was the key prerequisite for the successful preparation of the 1,2-alternate conformers, which are available without the use of any protecting groups.

    Research areas

  • 1,2-Alternate, Alkylation, Calixarene, Conformation, Conformational mobility, Partial cone

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations