A happy medium: the synthesis of medicinally important medium-sized rings: Via ring expansion

Aimee K. Clarke, William P. Unsworth*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Medium-sized rings have much promise in medicinal chemistry, but are difficult to make using direct cyclisation methods. In this minireview, we highlight the value of ring expansion strategies to address this long-standing synthetic challenge. We have drawn on recent progress (post 2013) to highlight the key reaction design features that enable successful 'normal-to-medium' ring expansion for the synthesis of these medicinally important molecular frameworks, that are currently under-represented in compound screening collections and marketed drugs in view of their challenging syntheses.

Original languageEnglish
Pages (from-to)2876-2881
Number of pages6
JournalChemical Science
Issue number11
Early online date2 Mar 2020
Publication statusPublished - 21 Mar 2020

Bibliographical note

© The Royal Society of Chemistry 2020

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