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From the same journal

A HIGHLY EFFICIENT FREE-RADICAL APPROACH TO TRISUBSTITUTED PYRROLIDINONES

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JournalJOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS
DatePublished - 7 Aug 1993
Issue number15
Number of pages2
Pages (from-to)1224-1225
Original languageEnglish

Abstract

The radical-mediated cyclisation of serine derived alpha-chloroamides has beer found to be influenced in both yield and stereoselectivity by the nature of the substituent at the site of radical generation-radicals substituted at the alpha-position by methyl, phenyl and dichloro groups underwent smooth cyclisation to give excellent yield of pyrrolidinones in which the trans-C-2 : C-3 isomer predominated-this procedure has potential application to a new synthesis of the kainoid amino acids.

    Research areas

  • ACROMELIC ACID, AMINO-ACIDS, ENANTIOSELECTIVE SYNTHESIS, CLITOCYBE-ACROMELALGA, MEDIATED CYCLIZATION, 5-MEMBERED LACTAMS, DOMOIC ACID, ROUTE

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