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A HIGHLY EFFICIENT FREE-RADICAL APPROACH TO TRISUBSTITUTED PYRROLIDINONES
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| Journal | JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS |
|---|---|
| Date | Published - 7 Aug 1993 |
| Issue number | 15 |
| Number of pages | 2 |
| Pages (from-to) | 1224-1225 |
| Original language | English |
Abstract
The radical-mediated cyclisation of serine derived alpha-chloroamides has beer found to be influenced in both yield and stereoselectivity by the nature of the substituent at the site of radical generation-radicals substituted at the alpha-position by methyl, phenyl and dichloro groups underwent smooth cyclisation to give excellent yield of pyrrolidinones in which the trans-C-2 : C-3 isomer predominated-this procedure has potential application to a new synthesis of the kainoid amino acids.
- ACROMELIC ACID, AMINO-ACIDS, ENANTIOSELECTIVE SYNTHESIS, CLITOCYBE-ACROMELALGA, MEDIATED CYCLIZATION, 5-MEMBERED LACTAMS, DOMOIC ACID, ROUTE
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