A hyperpolarized equilibrium for magnetic resonance

TY - JOUR

T1 - A hyperpolarized equilibrium for magnetic resonance

AU - Hövener, J.-B.

AU - Schwaderlapp, N.

AU - Lickert, T.

AU - Duckett, S.B.

AU - Mewis, R.E.

AU - Highton, L.A.R.

AU - Kenny, S.M.

AU - Green, G.G.R.

AU - Leibfritz, D.

AU - Korvink, J.G.

AU - Hennig, J.

AU - Von Elverfeldt, D.

PY - 2013/12/16

Y1 - 2013/12/16

N2 - Nuclear magnetic resonance spectroscopy and imaging (MRI) play an indispensable role in science and healthcare but use only a tiny fraction of their potential. No more than ≈10 p.p.m. of all 1 H nuclei are effectively detected in a 3-Tesla clinical MRI system. Thus, a vast array of new applications lays dormant, awaiting improved sensitivity. Here we demonstrate the continuous polarization of small molecules in solution to a level that cannot be achieved in a viable magnet. The magnetization does not decay and is effectively reinitialized within seconds after being measured. This effect depends on the long-lived, entangled spin-order of parahydrogen and an exchange reaction in a low magnetic field of 10-3 Tesla. We demonstrate the potential of this method by fast MRI and envision the catalysis of new applications such as cancer screening or indeed low-field MRI for routine use and remote application.

AB - Nuclear magnetic resonance spectroscopy and imaging (MRI) play an indispensable role in science and healthcare but use only a tiny fraction of their potential. No more than ≈10 p.p.m. of all 1 H nuclei are effectively detected in a 3-Tesla clinical MRI system. Thus, a vast array of new applications lays dormant, awaiting improved sensitivity. Here we demonstrate the continuous polarization of small molecules in solution to a level that cannot be achieved in a viable magnet. The magnetization does not decay and is effectively reinitialized within seconds after being measured. This effect depends on the long-lived, entangled spin-order of parahydrogen and an exchange reaction in a low magnetic field of 10-3 Tesla. We demonstrate the potential of this method by fast MRI and envision the catalysis of new applications such as cancer screening or indeed low-field MRI for routine use and remote application.

UR - http://www.scopus.com/inward/record.url?scp=84890633347&partnerID=8YFLogxK

U2 - 10.1038/ncomms3946

DO - 10.1038/ncomms3946

M3 - Article

AN - SCOPUS:84890633347

VL - 4

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2946

ER -