A key role for iodobenzene in the direct C-H bond functionalisation of benzoxazoles using PhI(OAc) mediated by a Pd(OAc) /1,10-phenanthroline catalyst system: In situ formation of well-defined Pd nanoparticles

T.J. Williams, I.J.S. Fairlamb

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PhI(OAc) has previously been reported as a reagent for the direct arylation of C-H bonds in benzoxazole in a Pd-mediated process. However, evidence reported here suggests this reagent degrades to iodobenzene under the literature reported reaction conditions. Further, we present evidence for the rapid formation of Pd nanoparticles in this reaction, leading us to question what is the active catalytic Pd phase in coupling chemistry?.
Original languageEnglish
Pages (from-to)2906-2908
JournalTetrahedron Letters
Issue number23
Publication statusPublished - 5 Jun 2013

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