The York Research Database

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

Saldivia Concepcion, M. A., Fang, E., Ma, X., Myburgh, E., Brambilla Carnielli Trindade, J., Bower-Lepts, C., Brown, E., Ritchie, R., Lakshminarayana, S. B., Chen, Y-L., Patra, D., Ornelas, E., Koh, H. X. Y., Williams, S., Supek, F., Paape, D., McCulloch, R., Kaiser, M., Barrett, M. P., Jiricek, J. & 3 others, Diagana, T. T., Mottram, J. C. & Rao, S. P. S., Oct 2020

Article in Nature Microbiology

Essential roles for deubiquitination in Leishmania life cycle progression

Damianou, A., Burge, R., Catta-Preta, C. M. C., Geoghegan, V. L., Nievas, R., Newling, K., Brown, E., Burchmore, R. J., Rodenko, B. & Mottram, J. C., 9 Jun 2020, (Accepted/In press)

Article in PLOS PATHOGENS

Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis

Forrester, S., Siefert, K., Ashwin, H., Brown, N., Zelmar, A., James, S., Lagos, D., Timmis, J., Chatterjee, M., Mottram, J. C., Croft, S. L. & Kaye, P. M., 10 Dec 2019

Article in Wellcome Open Research

Evaluation of Clan CD C11 peptidase PNT1 and other Leishmania mexicana cysteine peptidases as potential drug targets

Grewal, J., Catta Preta, C., Brown, E., Anand, J. & Mottram, J. C., 1 Nov 2019

Article in BIOCHIMIE

Natural Resistance of Leishmania infantum to Miltefosine Contributes to the Low Efficacy in the Treatment of Visceral Leishmaniasis in Brazil

Brambilla Carnielli Trindade, J., Monti-Rocha, R., Costa, D. L., Sesana, A. M., Pansini, L. N. N., Segatto, M., Mottram, J. C., Nery Costa, C. H., Carvalho, S. F. G. & Dietze, R., 2 Oct 2019

Article in American journal of tropical medicine and hygiene

Host transcriptomic signature as alternative test-of-cure in visceral leishmaniasis patients coinfected with HIV

Kaye, P., Adriaensen, W., Cuypers, B., Cordero, C. F., Mengasha, B., Blesson, S., Cnops, L., Alves, F., Diro, E. & van Griensven, J., May 2020

Article in EBioMedicine

Follicular Helper T Cells are Essential for the Elimination of Plasmodium Infection

Pérez-Mazliah, D., Nguyen, M. P., Hosking, C., McLaughlin, S., Lewis, M. D., Tumwine, I., Levy, P. & Langhorne, J., Oct 2017

Article in EBioMedicine