Projects per year
The Maitland–Japp reaction has been extended to the synthesis of highly functionalised dihydropyran-4-ones. These dihydropyran-4-ones can in turn be converted stereoselectively into tetrahydropyran-4-ones with tertiary and quaternary stereocentres via the one-pot addition of hydride or carbon nucleophiles and trapping with carbon electrophiles. The utility of this method is demonstrated by providing access to the functionalised tetrahydropyran units present in a component of the Civet fragrance and the anticancer polyketide lasonolide A.
- MAITLAND-JAPP REACTION
- Civet cat secretion
- 1 Finished
Clarke, P. A., Mad Nasir, M. & Sellars, P. B.
1/01/13 → 30/06/16
Project: Other project › Research collaboration