A mild and selective Pd-mediated methodology for the synthesis of highly fluorescent 2-arylated tryptophans and tryptophan-containing peptides: a catalytic role for Pd(0) nanoparticles?

Thomas J Williams, Alan J Reay, Adrian C Whitwood, Ian J S Fairlamb

Research output: Contribution to journalArticlepeer-review


A Pd-mediated direct C-H bond functionalisation of tryptophan has been developed, both as a single amino acid residue and within peptides. Important mechanistic insight into this process has been gained by characterising a Pd catalytically competent nanoparticle phase which evolves during the early stages of reaction.
Original languageEnglish
Pages (from-to)3052-4
Number of pages3
JournalChemical Communications
Issue number23
Early online date10 Feb 2014
Publication statusPublished - 2014

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