By the same authors

A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection

Research output: Contribution to journalArticlepeer-review

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A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection. / Annese, Valerio ; Patil, Samadhan Bhaulal; Hu, Chunxiao ; Giagkoulovits, Christos; Al-Rawhani, Mohammed ; Grant, James ; Macleod, Martin; Clayton, David; Heaney, Liam ; Daly, Ronan; Accarino, Claudio ; Shah, Yash; Cheah, Boon; Beeley, James; Jeffry Evans, Thomas ; Jones, Robert; Barrett, Michael ; Cumming, David.

In: Microsystems & Nanoengineering, Vol. 7, 21 (2021), 05.03.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Annese, V, Patil, SB, Hu, C, Giagkoulovits, C, Al-Rawhani, M, Grant, J, Macleod, M, Clayton, D, Heaney, L, Daly, R, Accarino, C, Shah, Y, Cheah, B, Beeley, J, Jeffry Evans, T, Jones, R, Barrett, M & Cumming, D 2021, 'A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection', Microsystems & Nanoengineering, vol. 7, 21 (2021). https://doi.org/10.1038/s41378-021-00243-4

APA

Annese, V., Patil, S. B., Hu, C., Giagkoulovits, C., Al-Rawhani, M., Grant, J., Macleod, M., Clayton, D., Heaney, L., Daly, R., Accarino, C., Shah, Y., Cheah, B., Beeley, J., Jeffry Evans, T., Jones, R., Barrett, M., & Cumming, D. (2021). A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection. Microsystems & Nanoengineering, 7, [ 21 (2021)]. https://doi.org/10.1038/s41378-021-00243-4

Vancouver

Annese V, Patil SB, Hu C, Giagkoulovits C, Al-Rawhani, M, Grant J et al. A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection. Microsystems & Nanoengineering. 2021 Mar 5;7. 21 (2021). https://doi.org/10.1038/s41378-021-00243-4

Author

Annese, Valerio ; Patil, Samadhan Bhaulal ; Hu, Chunxiao ; Giagkoulovits, Christos ; Al-Rawhani, Mohammed ; Grant, James ; Macleod, Martin ; Clayton, David ; Heaney, Liam ; Daly, Ronan ; Accarino, Claudio ; Shah, Yash ; Cheah, Boon ; Beeley, James ; Jeffry Evans, Thomas ; Jones, Robert ; Barrett, Michael ; Cumming, David. / A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection. In: Microsystems & Nanoengineering. 2021 ; Vol. 7.

Bibtex - Download

@article{2b942c96f4cd49dca1875385a958a125,
title = "A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection",
abstract = "There is a global unmet need for rapid and cost-effective prognostic and diagnostic tools that can be used at the bedside or in the doctor{\textquoteright}s office to reduce the impact of serious disease. Many cancers are diagnosed late, leading to costly treatment and reduced life expectancy. With prostate cancer, the absence of a reliable test has inhibited the adoption of screening programs. We report a microelectronic point-of-care metabolite biomarker measurement platform and use it for prostate cancer detection. The platform, using an array of photodetectors configured to operate with targeted, multiplexed, colorimetric assays confined in monolithically integrated passive microfluidic channels, completes a combined assay of 4 metabolites in a drop of human plasma in under 2 min. A preliminary clinical study using L-amino acids, glutamate, choline, and sarcosine was used to train a cross-validated random forest algorithm. The system demonstrated sensitivity to prostate cancer of 94% with a specificity of 70% and an area under the curve of 0.78. The technology can implement many similar assay panels and hence has the potential to revolutionize low-cost, rapid, point-of-care testing.",
keywords = "Prostate cancer, CMOS, point of care, microfluidics, METABOLOMICS",
author = "Valerio Annese and Patil, {Samadhan Bhaulal} and Chunxiao Hu and Christos Giagkoulovits and Mohammed Al-Rawhani, and James Grant and Martin Macleod and David Clayton and Liam Heaney and Ronan Daly and Claudio Accarino and Yash Shah and Boon Cheah and James Beeley and {Jeffry Evans}, Thomas and Robert Jones and Michael Barrett and David Cumming",
note = "{\textcopyright} The Author(s) 2021. ",
year = "2021",
month = mar,
day = "5",
doi = "10.1038/s41378-021-00243-4",
language = "English",
volume = "7",
journal = "Microsystems & Nanoengineering",
publisher = "Springer Nature",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection

AU - Annese, Valerio

AU - Patil, Samadhan Bhaulal

AU - Hu, Chunxiao

AU - Giagkoulovits, Christos

AU - Al-Rawhani,, Mohammed

AU - Grant, James

AU - Macleod, Martin

AU - Clayton, David

AU - Heaney, Liam

AU - Daly, Ronan

AU - Accarino, Claudio

AU - Shah, Yash

AU - Cheah, Boon

AU - Beeley, James

AU - Jeffry Evans, Thomas

AU - Jones, Robert

AU - Barrett, Michael

AU - Cumming, David

N1 - © The Author(s) 2021.

PY - 2021/3/5

Y1 - 2021/3/5

N2 - There is a global unmet need for rapid and cost-effective prognostic and diagnostic tools that can be used at the bedside or in the doctor’s office to reduce the impact of serious disease. Many cancers are diagnosed late, leading to costly treatment and reduced life expectancy. With prostate cancer, the absence of a reliable test has inhibited the adoption of screening programs. We report a microelectronic point-of-care metabolite biomarker measurement platform and use it for prostate cancer detection. The platform, using an array of photodetectors configured to operate with targeted, multiplexed, colorimetric assays confined in monolithically integrated passive microfluidic channels, completes a combined assay of 4 metabolites in a drop of human plasma in under 2 min. A preliminary clinical study using L-amino acids, glutamate, choline, and sarcosine was used to train a cross-validated random forest algorithm. The system demonstrated sensitivity to prostate cancer of 94% with a specificity of 70% and an area under the curve of 0.78. The technology can implement many similar assay panels and hence has the potential to revolutionize low-cost, rapid, point-of-care testing.

AB - There is a global unmet need for rapid and cost-effective prognostic and diagnostic tools that can be used at the bedside or in the doctor’s office to reduce the impact of serious disease. Many cancers are diagnosed late, leading to costly treatment and reduced life expectancy. With prostate cancer, the absence of a reliable test has inhibited the adoption of screening programs. We report a microelectronic point-of-care metabolite biomarker measurement platform and use it for prostate cancer detection. The platform, using an array of photodetectors configured to operate with targeted, multiplexed, colorimetric assays confined in monolithically integrated passive microfluidic channels, completes a combined assay of 4 metabolites in a drop of human plasma in under 2 min. A preliminary clinical study using L-amino acids, glutamate, choline, and sarcosine was used to train a cross-validated random forest algorithm. The system demonstrated sensitivity to prostate cancer of 94% with a specificity of 70% and an area under the curve of 0.78. The technology can implement many similar assay panels and hence has the potential to revolutionize low-cost, rapid, point-of-care testing.

KW - Prostate cancer

KW - CMOS

KW - point of care

KW - microfluidics

KW - METABOLOMICS

U2 - 10.1038/s41378-021-00243-4

DO - 10.1038/s41378-021-00243-4

M3 - Article

VL - 7

JO - Microsystems & Nanoengineering

JF - Microsystems & Nanoengineering

M1 - 21 (2021)

ER -