A New Evolutionary Algorithm-Based Home Monitoring Device for Parkinson’s Dyskinesia

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JournalJournal of medical systems
DateAccepted/In press - 29 Aug 2017
DateE-pub ahead of print - 25 Sep 2017
DatePublished (current) - 1 Nov 2017
Issue number11
Volume41
Number of pages8
Early online date25/09/17
Original languageEnglish

Abstract

Parkinson’s disease (PD) is a neurodegenerative movement disorder. Although there is no cure, symptomatic treatments are available and can significantly improve quality of life. The motor, or movement, features of PD are caused by reduced production of the neurotransmitter dopamine. Dopamine deficiency is most often treated using dopamine replacement therapy. However, this therapy can itself lead to further motor abnormalities referred to as dyskinesia. Dyskinesia consists of involuntary jerking movements and muscle spasms, which can often be violent. To minimise dyskinesia, it is necessary to accurately titrate the amount of medication given and monitor a patient’s movements. In this paper, we describe a new home monitoring device that allows dyskinesia to be measured as a patient goes about their daily activities, providing information that can assist clinicians when making changes to medication regimens. The device uses a predictive model of dyskinesia that was trained by an evolutionary algorithm, and achieves AUC>0.9 when discriminating clinically significant dyskinesia.

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© The Author(s) 2017

    Research areas

  • Dyskinesia, Genetic programming, Home monitoring, Parkinson’s disease

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