Research output: Contribution to journal › Article › peer-review
A New Evolutionary Algorithm-Based Home Monitoring Device for Parkinson’s Dyskinesia. / Lones, Michael A.; Alty, Jane E.; Cosgrove, Jeremy; Duggan-Carter, Philippa; Jamieson, Stuart; Naylor, Rebecca F.; Turner, Andrew J.; Smith, Stephen L.
In: Journal of medical systems, Vol. 41, No. 11, 176, 25.09.2017, p. 176.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - A New Evolutionary Algorithm-Based Home Monitoring Device for Parkinson’s Dyskinesia
AU - Lones, Michael A.
AU - Alty, Jane E.
AU - Cosgrove, Jeremy
AU - Duggan-Carter, Philippa
AU - Jamieson, Stuart
AU - Naylor, Rebecca F.
AU - Turner, Andrew J.
AU - Smith, Stephen L.
N1 - © The Author(s) 2017
PY - 2017/9/25
Y1 - 2017/9/25
N2 - Parkinson’s disease (PD) is a neurodegenerative movement disorder. Although there is no cure, symptomatic treatments are available and can significantly improve quality of life. The motor, or movement, features of PD are caused by reduced production of the neurotransmitter dopamine. Dopamine deficiency is most often treated using dopamine replacement therapy. However, this therapy can itself lead to further motor abnormalities referred to as dyskinesia. Dyskinesia consists of involuntary jerking movements and muscle spasms, which can often be violent. To minimise dyskinesia, it is necessary to accurately titrate the amount of medication given and monitor a patient’s movements. In this paper, we describe a new home monitoring device that allows dyskinesia to be measured as a patient goes about their daily activities, providing information that can assist clinicians when making changes to medication regimens. The device uses a predictive model of dyskinesia that was trained by an evolutionary algorithm, and achieves AUC>0.9 when discriminating clinically significant dyskinesia.
AB - Parkinson’s disease (PD) is a neurodegenerative movement disorder. Although there is no cure, symptomatic treatments are available and can significantly improve quality of life. The motor, or movement, features of PD are caused by reduced production of the neurotransmitter dopamine. Dopamine deficiency is most often treated using dopamine replacement therapy. However, this therapy can itself lead to further motor abnormalities referred to as dyskinesia. Dyskinesia consists of involuntary jerking movements and muscle spasms, which can often be violent. To minimise dyskinesia, it is necessary to accurately titrate the amount of medication given and monitor a patient’s movements. In this paper, we describe a new home monitoring device that allows dyskinesia to be measured as a patient goes about their daily activities, providing information that can assist clinicians when making changes to medication regimens. The device uses a predictive model of dyskinesia that was trained by an evolutionary algorithm, and achieves AUC>0.9 when discriminating clinically significant dyskinesia.
KW - Dyskinesia
KW - Genetic programming
KW - Home monitoring
KW - Parkinson’s disease
UR - http://www.scopus.com/inward/record.url?scp=85029848571&partnerID=8YFLogxK
U2 - 10.1007/s10916-017-0811-7
DO - 10.1007/s10916-017-0811-7
M3 - Article
C2 - 28948460
AN - SCOPUS:85029848571
VL - 41
SP - 176
JO - Journal of medical systems
JF - Journal of medical systems
SN - 0148-5598
IS - 11
M1 - 176
ER -