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A Next Generation of Advances in Chromosome Architecture

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JournalMethods in Molecular Biology
DateAccepted/In press - 16 Feb 2022
DatePublished (current) - 31 May 2022
Volume2476
Number of pages3
Pages (from-to)1-3
Original languageEnglish

Abstract

New insight into the architecture of chromosomes, their molecular composition, structure and spatial location, and time-resolved features, has grown enormously through developments of a range of pioneering interdisciplinary approaches that lie at the interface of the life and physical sciences. These involve several state-of-the-art "physics of life" tools that are both experimental and theoretical, used in conjunction with molecular biology methods which enable investigation of chromosome structure and function in vitro, in vivo, and even in silico. In particular, a move towards far greater quantitation has enabled transformative leaps in our understanding. These have involved valuable improvements to the spatial and temporal resolution of quantitative measurements, such as in vivo super-resolved light microscopy and single-molecule biophysics methods, which facilitate probing of dynamic chromosome processes hitherto impossible. Similarly, there have been important advances in the theoretical biophysics approaches which have enabled advances in predictive modeling to generate new understanding of the modes of operation of chromosomes across all domains of life. Here, I discuss these advances, and review the current state of our knowledge of chromosome architecture and speculation where future advances may lead.

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© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

    Research areas

  • Chromosomes/genetics, Nanotechnology

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