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A novel approach for characterising pH-dependent uptake of ionisable chemicals in aquatic organisms

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JournalEnvironmental science & technology
DateAccepted/In press - 29 May 2017
DateE-pub ahead of print - 29 May 2017
DatePublished (current) - 20 Jun 2017
Volume51
Number of pages7
Pages (from-to)6965−6971
Early online date29/05/17
Original languageEnglish

Abstract

Here, we present and evaluate a combined experimental and modelling approach for characterising the uptake of ionisable chemicals from water and sediments into aquatic organisms under different pH conditions. We illustrate and evaluate the approach for two pharmaceuticals (diclofenac and fluoxetine) and one personal care product ingredient (triclosan) for the oligochaete Lumbriculus variegatus. Initially, experimental data on the uptake of the three chemicals at two pH values were fitted using a toxicokinetic model to derive uptake and depuration constants for the neutral and ionised species of each molecule. The derived constants were then used to predict uptake from water and sediment for other pH conditions. Evaluation of predictions against corresponding experimental data showed good predictions of uptake for all test chemicals from water for different pH conditions and reasonable predictions of uptake of fluoxetine and diclofenac from a sediment. Predictions demonstrated that the level of uptake of the study chemicals, across pH ranges in European streams, could differ by up to a factor of 3035. Overall, the approach could be extremely useful for assessing internal exposure of aquatic organisms across landscapes with differing pH. This could help support better characterisation of the risks of ionisable chemicals in the aquatic environment.

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© 2017 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

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