By the same authors

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From the same journal

A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials

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A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials. / Pujari-Palmer, Michael; Guo, Hua; Wenner, David; Autefage, Hélène; Spicer, Christopher D; Stevens, Molly M; Omar, Omar; Thomsen, Peter; Edén, Mattias; Insley, Gerard; Procter, Philip; Engqvist, Hakan.

In: Materials, Vol. 11, No. 12, 07.12.2018.

Research output: Contribution to journalArticlepeer-review

Harvard

Pujari-Palmer, M, Guo, H, Wenner, D, Autefage, H, Spicer, CD, Stevens, MM, Omar, O, Thomsen, P, Edén, M, Insley, G, Procter, P & Engqvist, H 2018, 'A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials', Materials, vol. 11, no. 12. https://doi.org/10.3390/ma11122492

APA

Pujari-Palmer, M., Guo, H., Wenner, D., Autefage, H., Spicer, C. D., Stevens, M. M., Omar, O., Thomsen, P., Edén, M., Insley, G., Procter, P., & Engqvist, H. (2018). A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials. Materials, 11(12). https://doi.org/10.3390/ma11122492

Vancouver

Pujari-Palmer M, Guo H, Wenner D, Autefage H, Spicer CD, Stevens MM et al. A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials. Materials. 2018 Dec 7;11(12). https://doi.org/10.3390/ma11122492

Author

Pujari-Palmer, Michael ; Guo, Hua ; Wenner, David ; Autefage, Hélène ; Spicer, Christopher D ; Stevens, Molly M ; Omar, Omar ; Thomsen, Peter ; Edén, Mattias ; Insley, Gerard ; Procter, Philip ; Engqvist, Hakan. / A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials. In: Materials. 2018 ; Vol. 11, No. 12.

Bibtex - Download

@article{b90c3395e4904f6095ea520c410450eb,
title = "A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials",
abstract = "Calcium phosphate cements (CPCs) are clinically effective void fillers that are capable of bridging calcified tissue defects and facilitating regeneration. However, CPCs are completely synthetic/inorganic, unlike the calcium phosphate that is found in calcified tissues, and they lack an architectural organization, controlled assembly mechanisms, and have moderate biomechanical strength, which limits their clinical effectiveness. Herein, we describe a new class of bioinspired CPCs that can glue tissues together and bond tissues to metallic and polymeric biomaterials. Surprisingly, alpha tricalcium phosphate cements that are modified with simple phosphorylated amino acid monomers of phosphoserine (PM-CPCs) bond tissues up to 40-fold stronger (2.5⁻4 MPa) than commercial cyanoacrylates (0.1 MPa), and 100-fold stronger than surgical fibrin glue (0.04 MPa), when cured in wet-field conditions. In addition to adhesion, phosphoserine creates other novel properties in bioceramics, including a nanoscale organic/inorganic composite microstructure, and templating of nanoscale amorphous calcium phosphate nucleation. PM-CPCs are made of the biocompatible precursors calcium, phosphate, and amino acid, and these represent the first amorphous nano-ceramic composites that are stable in liquids.",
author = "Michael Pujari-Palmer and Hua Guo and David Wenner and H{\'e}l{\`e}ne Autefage and Spicer, {Christopher D} and Stevens, {Molly M} and Omar Omar and Peter Thomsen and Mattias Ed{\'e}n and Gerard Insley and Philip Procter and Hakan Engqvist",
note = "{\textcopyright} 2018 by the authors.",
year = "2018",
month = dec,
day = "7",
doi = "10.3390/ma11122492",
language = "English",
volume = "11",
journal = "Materials",
issn = "1996-1944",
publisher = "American Institute of Physics",
number = "12",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials

AU - Pujari-Palmer, Michael

AU - Guo, Hua

AU - Wenner, David

AU - Autefage, Hélène

AU - Spicer, Christopher D

AU - Stevens, Molly M

AU - Omar, Omar

AU - Thomsen, Peter

AU - Edén, Mattias

AU - Insley, Gerard

AU - Procter, Philip

AU - Engqvist, Hakan

N1 - © 2018 by the authors.

PY - 2018/12/7

Y1 - 2018/12/7

N2 - Calcium phosphate cements (CPCs) are clinically effective void fillers that are capable of bridging calcified tissue defects and facilitating regeneration. However, CPCs are completely synthetic/inorganic, unlike the calcium phosphate that is found in calcified tissues, and they lack an architectural organization, controlled assembly mechanisms, and have moderate biomechanical strength, which limits their clinical effectiveness. Herein, we describe a new class of bioinspired CPCs that can glue tissues together and bond tissues to metallic and polymeric biomaterials. Surprisingly, alpha tricalcium phosphate cements that are modified with simple phosphorylated amino acid monomers of phosphoserine (PM-CPCs) bond tissues up to 40-fold stronger (2.5⁻4 MPa) than commercial cyanoacrylates (0.1 MPa), and 100-fold stronger than surgical fibrin glue (0.04 MPa), when cured in wet-field conditions. In addition to adhesion, phosphoserine creates other novel properties in bioceramics, including a nanoscale organic/inorganic composite microstructure, and templating of nanoscale amorphous calcium phosphate nucleation. PM-CPCs are made of the biocompatible precursors calcium, phosphate, and amino acid, and these represent the first amorphous nano-ceramic composites that are stable in liquids.

AB - Calcium phosphate cements (CPCs) are clinically effective void fillers that are capable of bridging calcified tissue defects and facilitating regeneration. However, CPCs are completely synthetic/inorganic, unlike the calcium phosphate that is found in calcified tissues, and they lack an architectural organization, controlled assembly mechanisms, and have moderate biomechanical strength, which limits their clinical effectiveness. Herein, we describe a new class of bioinspired CPCs that can glue tissues together and bond tissues to metallic and polymeric biomaterials. Surprisingly, alpha tricalcium phosphate cements that are modified with simple phosphorylated amino acid monomers of phosphoserine (PM-CPCs) bond tissues up to 40-fold stronger (2.5⁻4 MPa) than commercial cyanoacrylates (0.1 MPa), and 100-fold stronger than surgical fibrin glue (0.04 MPa), when cured in wet-field conditions. In addition to adhesion, phosphoserine creates other novel properties in bioceramics, including a nanoscale organic/inorganic composite microstructure, and templating of nanoscale amorphous calcium phosphate nucleation. PM-CPCs are made of the biocompatible precursors calcium, phosphate, and amino acid, and these represent the first amorphous nano-ceramic composites that are stable in liquids.

U2 - 10.3390/ma11122492

DO - 10.3390/ma11122492

M3 - Article

C2 - 30544596

VL - 11

JO - Materials

JF - Materials

SN - 1996-1944

IS - 12

ER -