A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression

Céline Vallot; Nicolas Stransky; Isabelle Bernard-Pierrot; Aurélie Hérault; Jessica Zucman-Rossi; Elodie Chapeaublanc; Dimitri Vordos; Agnès Laplanche; Simone Benhamou; Thierry Lebret; Jennifer Southgate; Yves Allory; François Radvanyi

doi:10.1093/jnci/djq470

A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression

Céline Vallot, Nicolas Stransky, Isabelle Bernard-Pierrot, Aurélie Hérault, Jessica Zucman-Rossi, Elodie Chapeaublanc, Dimitri Vordos, Agnès Laplanche, Simone Benhamou, Thierry Lebret, Jennifer Southgate, Yves Allory, François Radvanyi

Jack Birch Unit

Research output: Contribution to journal › Article › peer-review

Abstract

Epigenetic silencing can extend to whole chromosomal regions in cancer. There have been few genome-wide studies exploring its involvement in tumorigenesis.

Original language	English
Pages (from-to)	47-60
Number of pages	14
Journal	Journal of the National Cancer Institute
Volume	103
Issue number	1
DOIs	https://doi.org/10.1093/jnci/djq470
Publication status	Published - 5 Jan 2011

Keywords

Adult
Aged
Aged, 80 and over
Carcinoma in Situ
Cell Line, Tumor
Chromatin
Cluster Analysis
DNA Methylation
Disease Progression
Epigenesis, Genetic
Female
Gene Expression Regulation, Neoplastic
Gene Silencing
Genes, Tumor Suppressor
Histones
Humans
Immunoprecipitation
Male
Microarray Analysis
Middle Aged
Mutation
Neoplasm Staging
Phenotype
RNA, Neoplasm
Receptor, Fibroblast Growth Factor, Type 3
Reverse Transcriptase Polymerase Chain Reaction
Urinary Bladder Neoplasms

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10.1093/jnci/djq470

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Vallot, C., Stransky, N., Bernard-Pierrot, I., Hérault, A., Zucman-Rossi, J., Chapeaublanc, E., Vordos, D., Laplanche, A., Benhamou, S., Lebret, T., Southgate, J., Allory, Y., & Radvanyi, F. (2011). A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression. Journal of the National Cancer Institute, 103(1), 47-60. https://doi.org/10.1093/jnci/djq470

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title = "A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression",

abstract = "Epigenetic silencing can extend to whole chromosomal regions in cancer. There have been few genome-wide studies exploring its involvement in tumorigenesis.",

keywords = "Adult, Aged, Aged, 80 and over, Carcinoma in Situ, Cell Line, Tumor, Chromatin, Cluster Analysis, DNA Methylation, Disease Progression, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Gene Silencing, Genes, Tumor Suppressor, Histones, Humans, Immunoprecipitation, Male, Microarray Analysis, Middle Aged, Mutation, Neoplasm Staging, Phenotype, RNA, Neoplasm, Receptor, Fibroblast Growth Factor, Type 3, Reverse Transcriptase Polymerase Chain Reaction, Urinary Bladder Neoplasms",

author = "C{\'e}line Vallot and Nicolas Stransky and Isabelle Bernard-Pierrot and Aur{\'e}lie H{\'e}rault and Jessica Zucman-Rossi and Elodie Chapeaublanc and Dimitri Vordos and Agn{\`e}s Laplanche and Simone Benhamou and Thierry Lebret and Jennifer Southgate and Yves Allory and Fran{\c c}ois Radvanyi",

year = "2011",

month = jan,

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doi = "10.1093/jnci/djq470",

language = "English",

volume = "103",

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Vallot, C, Stransky, N, Bernard-Pierrot, I, Hérault, A, Zucman-Rossi, J, Chapeaublanc, E, Vordos, D, Laplanche, A, Benhamou, S, Lebret, T, Southgate, J, Allory, Y & Radvanyi, F 2011, 'A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression', Journal of the National Cancer Institute, vol. 103, no. 1, pp. 47-60. https://doi.org/10.1093/jnci/djq470

TY - JOUR

T1 - A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression

AU - Vallot, Céline

AU - Stransky, Nicolas

AU - Bernard-Pierrot, Isabelle

AU - Hérault, Aurélie

AU - Zucman-Rossi, Jessica

AU - Chapeaublanc, Elodie

AU - Vordos, Dimitri

AU - Laplanche, Agnès

AU - Benhamou, Simone

AU - Lebret, Thierry

AU - Southgate, Jennifer

AU - Allory, Yves

AU - Radvanyi, François

PY - 2011/1/5

Y1 - 2011/1/5

N2 - Epigenetic silencing can extend to whole chromosomal regions in cancer. There have been few genome-wide studies exploring its involvement in tumorigenesis.

AB - Epigenetic silencing can extend to whole chromosomal regions in cancer. There have been few genome-wide studies exploring its involvement in tumorigenesis.

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KW - Aged

KW - Aged, 80 and over

KW - Carcinoma in Situ

KW - Cell Line, Tumor

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KW - Cluster Analysis

KW - DNA Methylation

KW - Disease Progression

KW - Epigenesis, Genetic

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Gene Silencing

KW - Genes, Tumor Suppressor

KW - Histones

KW - Humans

KW - Immunoprecipitation

KW - Male

KW - Microarray Analysis

KW - Middle Aged

KW - Mutation

KW - Neoplasm Staging

KW - Phenotype

KW - RNA, Neoplasm

KW - Receptor, Fibroblast Growth Factor, Type 3

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Urinary Bladder Neoplasms

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DO - 10.1093/jnci/djq470

M3 - Article

C2 - 21173382

SN - 1460-2105

VL - 103

SP - 47

EP - 60

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 1

ER -

A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression

Abstract

Keywords

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