A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression

Céline Vallot, Nicolas Stransky, Isabelle Bernard-Pierrot, Aurélie Hérault, Jessica Zucman-Rossi, Elodie Chapeaublanc, Dimitri Vordos, Agnès Laplanche, Simone Benhamou, Thierry Lebret, Jennifer Southgate, Yves Allory, François Radvanyi

Research output: Contribution to journalArticlepeer-review


Epigenetic silencing can extend to whole chromosomal regions in cancer. There have been few genome-wide studies exploring its involvement in tumorigenesis.
Original languageEnglish
Pages (from-to)47-60
Number of pages14
JournalJournal of the National Cancer Institute
Issue number1
Publication statusPublished - 5 Jan 2011


  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma in Situ
  • Cell Line, Tumor
  • Chromatin
  • Cluster Analysis
  • DNA Methylation
  • Disease Progression
  • Epigenesis, Genetic
  • Female
  • Gene Expression Regulation, Neoplastic
  • Gene Silencing
  • Genes, Tumor Suppressor
  • Histones
  • Humans
  • Immunoprecipitation
  • Male
  • Microarray Analysis
  • Middle Aged
  • Mutation
  • Neoplasm Staging
  • Phenotype
  • RNA, Neoplasm
  • Receptor, Fibroblast Growth Factor, Type 3
  • Reverse Transcriptase Polymerase Chain Reaction
  • Urinary Bladder Neoplasms

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