Abstract
BBK32 is a surface expressed lipoprotein and fibronectin (Fn)-binding microbial surface component recognizing adhesive matrix molecule (MSCRAMM) of Borrelia burgdorferi, the causative agent of Lyme disease. Previous studies from our group showed that BBK32 is a virulence factor in experimental Lyme disease and located the Fn-binding region to residues 21-205 of the lipoprotein.
Original language | English |
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Article number | e5412 |
Pages (from-to) | e5412 |
Journal | PLoS ONE |
Volume | 4 |
Issue number | 4 |
DOIs | |
Publication status | Published - 30 Apr 2009 |
Keywords
- Adhesins, Bacterial
- Amino Acid Motifs
- Bacterial Proteins
- Binding Sites
- Borrelia burgdorferi
- Cells, Cultured
- Endothelial Cells
- Fibroblasts
- Fibronectins
- Humans
- Lyme Disease
- Peptide Fragments
- Protein Binding
- Protein Multimerization
- Receptors, Virus
- Virulence Factors