A novel fibronectin binding motif in MSCRAMMs targets F3 modules

Sabitha Prabhakaran, Xiaowen Liang, Jonathan T Skare, Jennifer R Potts, Magnus Höök

Research output: Contribution to journalArticlepeer-review


BBK32 is a surface expressed lipoprotein and fibronectin (Fn)-binding microbial surface component recognizing adhesive matrix molecule (MSCRAMM) of Borrelia burgdorferi, the causative agent of Lyme disease. Previous studies from our group showed that BBK32 is a virulence factor in experimental Lyme disease and located the Fn-binding region to residues 21-205 of the lipoprotein.
Original languageEnglish
Article numbere5412
Pages (from-to)e5412
JournalPLoS ONE
Issue number4
Publication statusPublished - 30 Apr 2009


  • Adhesins, Bacterial
  • Amino Acid Motifs
  • Bacterial Proteins
  • Binding Sites
  • Borrelia burgdorferi
  • Cells, Cultured
  • Endothelial Cells
  • Fibroblasts
  • Fibronectins
  • Humans
  • Lyme Disease
  • Peptide Fragments
  • Protein Binding
  • Protein Multimerization
  • Receptors, Virus
  • Virulence Factors

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