By the same authors

From the same journal

A novel short approach to (Z)-Pulchellalactam through transition-metal-catalyzed atom-transfer radical cyclization of 1-isopropylprop-2-enyl dichloroacetate

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

  • Fulvia Felluga
  • Franco Ghelfi
  • Ugo M. Pagnoni
  • Andrew F. Parsons
  • Mariella Pattarozzi
  • Fabrizio Roncaglia
  • Ennio Valentin

Department/unit(s)

Publication details

JournalSYNTHESIS-STUTTGART
DatePublished - 18 Jun 2007
Issue number12
Number of pages5
Pages (from-to)1882-1886
Original languageEnglish

Abstract

A new, five-step route to (Z)-pulchelialactam, a CD45 protein tyrosine phosphatase inhibitor, is presented. Key steps are the copper(I) chloride bipyridyl catalyzed atom-transfer radical cyclization of an appropriate allyl alpha,alpha-dichloroacetate and the subsequent dehydrochlorination/prototropic rearrangement of the resulting dichlorolactone.

    Research areas

  • cyclizations, eliminations, lactams, lactones, radical reactions, TYROSINE-PHOSPHATASE INHIBITOR, FUNGUS COROLLOSPORA-PULCHELLA, LYMPHOCYTE-ACTIVATION, FACILE SYNTHESIS, GAMMA-LACTONES, CUCL-TMEDA, CD45, N-ALLYL-N-BENZYL-2,2-DIHALOAMIDES, REARRANGEMENT, HETEROCYCLES

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